Ahmed Adnan, Weldegebreal Fitsum, Tebeje Fikru, Dessie Yadeta
Eastern Harargi Health Bureau, Oromia, Ethiopia.
School Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Medicine (Baltimore). 2024 May 3;103(18):e38034. doi: 10.1097/MD.0000000000038034.
Tuberculosis (TB) and human immunodeficiency virus (HIV) coinfection pose significant challenges to global health, particularly in achieving the target of ending TB. However, the impact of HIV status on TB treatment outcomes remains unclear, especially in eastern Ethiopia. This study aimed to assess the treatment outcomes of TB cases by HIV status and associated factors in Haramaya General Hospital from November 15 to December 30, 2022. A retrospective cross-sectional study was conducted, reviewing the TB registry and treatment cards of patients who received anti-TB treatment between September 2017 and August 2022. Of the 420 samples addressed, 91.0% (95% CI: 88.3%-96.7%) of all TB patients had successful treatment outcomes. The treatment success rates of HIV-positive and HIV-negative TB patients were 80.0% and 91.9%, respectively. Being HIV-negative (AOR: 2.561, 95% CI: 1.002-6.542), being in the age group of 20 to 35 years (AOR: 2.950, 95% CI: 1.171-7.431), and urban residence (AOR: 2.961, 95% CI: 1.466-5.981) were associated with the TB treatment success rate. There was a high treatment success rate among all patients with TB. HIV status was associated with TB treatment outcomes. Strengthening TB-HIV collaborative activities, providing patient-centered care and support, and frequent monitoring and evaluation are recommended to improve the TB success rate.
结核病（TB）与人类免疫缺陷病毒（HIV）合并感染给全球卫生带来了重大挑战，尤其是在实现终结结核病目标方面。然而，HIV感染状况对结核病治疗结果的影响仍不明确，在埃塞俄比亚东部地区尤为如此。本研究旨在评估2022年11月15日至12月30日期间在哈拉马亚综合医院中，不同HIV感染状况的结核病病例的治疗结果及其相关因素。开展了一项回顾性横断面研究，查阅了2017年9月至2022年8月期间接受抗结核治疗患者的结核病登记册和治疗卡。在420份样本中，所有结核病患者的治疗成功率为91.0%（95%置信区间：88.3%-96.7%）。HIV阳性和HIV阴性结核病患者的治疗成功率分别为80.0%和91.9%。HIV阴性（调整后比值比：2.561，95%置信区间：1.002-6.542）、年龄在20至35岁之间（调整后比值比：2.950，95%置信区间：1.171-7.431）以及城市居住（调整后比值比：2.961，95%置信区间：1.466-5.981）与结核病治疗成功率相关。所有结核病患者的治疗成功率较高。HIV感染状况与结核病治疗结果相关。建议加强结核病与HIV的合作活动，提供以患者为中心的护理和支持，并进行频繁的监测和评估，以提高结核病治疗成功率。
