埃塞俄比亚奥罗米亚州塞贝塔的阿勒根纳健康中心的结核病治疗结果和相关因素。

Tuberculosis treatment outcomes and associated factors at Alemgena Health Center, Sebeta, Oromia, Ethiopia.

机构信息

Department of Public Health, Ayer Tena Health Science and Business College, Addis Ababa, Ethiopia.

Department of Microbial, Cellular and Molecular Biology, Adids Ababa University, Addis Ababa, Ethiopia.

出版信息

PLoS One. 2024 May 21;19(5):e0303797. doi: 10.1371/journal.pone.0303797. eCollection 2024.

Abstract

BACKGROUND

Tuberculosis (TB) is a global public health problem. Evaluation of TB treatment outcome enables health institutions to measure and improve the effectiveness of TB control programs. This study aimed to assess treatment outcomes of tuberculosis and identify associated factors among TB patients registered at Alemgena Health Center, Oromia, Ethiopia.

METHOD

A retrospective study was conducted; Secondary data were collected from medical records of 1010 TB patients treated at Alemgena Health Center between September 2012 and August 2018, inclusively. Logistic regression was used to identify factors associated with TB treatment outcomes. P-value less than 0.05 was considered statistically significant.

RESULTS

The proportion of males and females was almost equal. Among the patients 64.7% were in the age group 15-34, 98% were new cases, 31.2% were smear positive, 13% were HIV positive and 40.3% had extra-pulmonary tuberculosis. 94.2% of the patients had successful treatment outcome, with 26.9% cured and 67.3% treatment completed, whereas 5.8% had unsuccessful treatment outcomes, of whom 4.2% died and 1.5% defaulted. Death rate was higher among patients older than 44 years (10.4%) than among children (0%). In bivariate logistic regression analysis, treatment success rate was 3.582 (95% CI 1.958-6.554, p-value = .000) times higher in the age group 44 and below compared to the age group 45 and above.

CONCLUSION

Treatment success rate exceeded the one targeted by WHO. Age was found to be associated with treatment outcome. Success rate has to be improved for TB patients in the age group greater than 45 years of age.

摘要

背景

结核病(TB)是一个全球性的公共卫生问题。评估结核病的治疗结果使卫生机构能够衡量和提高结核病控制规划的有效性。本研究旨在评估在埃塞俄比亚奥罗米亚的 Alemgena 保健中心登记的结核病患者的治疗结果,并确定相关因素。

方法

这是一项回顾性研究;从 2012 年 9 月至 2018 年 8 月期间在 Alemgena 保健中心接受治疗的 1010 例结核病患者的病历中收集了二级数据。使用逻辑回归来确定与结核病治疗结果相关的因素。P 值小于 0.05 被认为具有统计学意义。

结果

男女比例几乎相等。在患者中,64.7%的年龄在 15-34 岁之间,98%是新发病例,31.2%是涂片阳性,13%是 HIV 阳性,40.3%是肺外结核病。94.2%的患者治疗结果成功,其中 26.9%治愈,67.3%完成治疗,而 5.8%的患者治疗结果不成功,其中 4.2%死亡,1.5%失访。44 岁及以上患者的死亡率(10.4%)高于儿童(0%)。在二变量逻辑回归分析中,年龄在 44 岁及以下的患者治疗成功率是年龄在 45 岁及以上患者的 3.582 倍(95%CI 1.958-6.554,p 值=0.000)。

结论

治疗成功率超过了世卫组织的目标。年龄与治疗结果有关。对于年龄在 45 岁以上的结核病患者,治疗成功率有待提高。

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