Sun Yueqian, Ren Guoping, Ren Jiechuan, Shan Wei, Han Xiong, Lian Yajun, Wang Tiancheng, Wang Qun
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China.
Front Neurol. 2020 Dec 29;11:612632. doi: 10.3389/fneur.2020.612632. eCollection 2020.
This study aims to evaluate the association between age and prognosis in patients with anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) under the age of 45 years. A retrospective study was conducted in patients younger than 45 years diagnosed as anti-NMDARE in four hospitals in China. Age at admission was divided into four categories: <15, 15-24, 25-34, 35-45 years. Neurological prognosis was evaluated using modified Rankin Scale. Adjusted multivariable logistic regression was used to analyze the association. The multivariable-adjusted odds ratios (95% confidence interval) of prognosis in anti-NMDARE across the categories of age were as follows: in males, 1.00 (reference), 4.76 (0.39-58.76), 13.50 (0.79-230.40), and 8.81 (0.36-218.39) ( for trend = 0.171); in females, 1.00 (reference), 7.27 (0.36-146.19), 20.08 (1.09-370.39), and 54.41 (1.60-1,849.10) ( for trend = 0.01). We concluded that the increasing age was associated with a poorer prognosis of anti-NMDARE in females but not males.
本研究旨在评估45岁以下抗N-甲基-D-天冬氨酸受体脑炎（抗NMDARE）患者的年龄与预后之间的关联。对中国四家医院诊断为抗NMDARE的45岁以下患者进行了一项回顾性研究。入院时年龄分为四类：<15岁、15 - 24岁、25 - 34岁、35 - 45岁。使用改良Rankin量表评估神经学预后。采用校正多变量逻辑回归分析这种关联。抗NMDARE患者在不同年龄组的多变量校正优势比（95%置信区间）如下：男性为1.00（参照）、4.76（0.39 - 58.76）、13.50（0.79 - 230.40）和8.81（0.36 - 218.39）（趋势检验P = 0.171）；女性为1.00（参照）、7.27（0.36 - 146.19）、20.08（1.09 - 370.39）和54.41（1.60 - 1,849.10）（趋势检验P = 0.01）。我们得出结论，年龄增加与女性抗NMDARE患者预后较差相关，但与男性无关。
