新型冠状病毒SARS-CoV-2的叙述性综述：基因组特征、传播及动物模型的最新进展
Narrative review of the novel coronavirus SARS-CoV-2: update on genomic characteristics, transmissions and animal model.
作者信息
Zhang Zhaoyong, Zhang Lu, Zhu Airu, Wang Yanqun, Guan Wenda, Zeng Zhiqi, Sun Jing, Li Fang, Zhao Jingxian, Yang Zifeng, Zhao Jincun, Zhong Nanshan
机构信息
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Technology Center, Guangzhou Custom, Guangzhou, China.
出版信息
J Thorac Dis. 2020 Dec;12(12):7454-7466. doi: 10.21037/jtd-20-2084.
Two outbreaks of severe respiratory infection caused by severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) caused global pandemics and highlighted the importance of preparedness for respiratory CoVs. Recently, a third highly pathogenic CoV, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, Hubei, China and posed a public health crisis worldwide. Here, we focus on the recent advances of the novel CoV, and discuss its genomic similarity with other CoVs, transmission, animal model and clinical treatment of coronavirus disease 2019 (COVID-19) induced by SARS-CoV-2, which help epidemic prevention and control, and guide treatment strategies.
由严重急性呼吸综合征冠状病毒（SARS-CoV）和中东呼吸综合征冠状病毒（MERS-CoV）引起的两次严重呼吸道感染爆发导致了全球大流行，并凸显了对呼吸道冠状病毒做好防范准备的重要性。最近，第三种高致病性冠状病毒——严重急性呼吸综合征冠状病毒2（SARS-CoV-2）——首次在中国湖北武汉被发现，并在全球范围内引发了公共卫生危机。在此，我们重点关注这种新型冠状病毒的最新进展，并讨论其与其他冠状病毒的基因组相似性、传播、动物模型以及由SARS-CoV-2引起的2019冠状病毒病（COVID-19）的临床治疗，这些有助于疫情防控并指导治疗策略。
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