Ji Chunpeng, Gao Jingli, Huang Zhe, Chen Shuohua, Wang Guodong, Wu Shouling, Jonas Jost B
Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, 063000, China.
Intensive-Care Unit, Kailuan General Hospital, North China University of Science and Technology, Tangshan, 063000, China.
Int J Cardiol Hypertens. 2020 Nov 11;7:100063. doi: 10.1016/j.ijchy.2020.100063. eCollection 2020 Dec.
The estimated pulse-wave velocity (ePWV) as measure for arterial wall stiffness is associated with an increased risk of cardiovascular disease (CVDs) and all-cause death in Western populations. We investigated the association between ePWV and the incidence of CVDs (myocardial infarction, cerebral infarction, cerebral hemorrhage) and all-cause death in Chinese. The community-based longitudinal Kailuan Study included 98,348 participants undergoing biennial clinical examinations. During a mean follow-up of 10.32 ± 2.14 years, 6967 CVD events (myocardial infarction, n = 1610; cerebral infarction, n = 4634; cerebral hemorrhage, n = 1071) and 9780 all-cause deaths occurred. Stratified by age, sex and presence of cardiovascular risk factors, the incidence of CVDs and all-cause death were higher ( < 0.01) in individuals with ePWV values ≥ 10 m/s than in those with ePWV values < 10 m/s. After adjusting for age, age squared and other conventional cardiovascular risk factors, an ePWV value of ≥10 m/s or each ePWV increase by 1 m/s increased ( < 0.01) the risk for CVDs by 32% (Hazard ratio (HR):1.32; 95% confidence interval (CI):1.23-1.42) and 22% (HR:1.22; 95%CI:1.18-1.27), respectively, and increased the risk for all-cause death significantly ( < 0.01) by 28% (HR:1.28; 95%CI:1.20-1.37) and 10% (HR:1.10; 95%CI:1.07-1.13), respectively. The mean brachial-ankle PWV, measured in 43,208 individuals, was 15.30 ± 3.51 cm/s, with a mean difference of 6.45 m/s (95% limits of agreement:1.24-11.7) to the ePWV. Independently of cardiovascular risk factors, ePWV was associated with CVDs and all-cause mortality in Chinese.
作为动脉壁硬度测量指标的估计脉搏波速度（ePWV）与西方人群中心血管疾病（CVD）风险增加及全因死亡相关。我们在中国人群中研究了ePWV与CVD（心肌梗死、脑梗死、脑出血）发病率及全因死亡之间的关联。基于社区的开滦纵向研究纳入了98348名接受两年一次临床检查的参与者。在平均10.32±2.14年的随访期间，发生了6967例CVD事件（心肌梗死，n = 1610；脑梗死，n = 4634；脑出血，n = 1071）和9780例全因死亡。按年龄、性别和心血管危险因素分层，ePWV值≥10 m/s的个体中CVD发病率和全因死亡率高于（<0.01）ePWV值<10 m/s的个体。在调整年龄、年龄平方和其他传统心血管危险因素后，ePWV值≥10 m/s或ePWV每增加1 m/s，CVD风险分别增加（<0.01）32%（风险比（HR）：1.32；95%置信区间（CI）：1.23 - 1.42）和22%（HR：1.22；95%CI：1.18 - 1.27），全因死亡风险分别显著增加（<0.01）28%（HR：1.28；95%CI：1.20 - 1.37）和10%（HR：1.10；95%CI：1.07 - 1.13）。在43208名个体中测量的平均臂踝脉搏波速度为15.30±3.51 cm/s，与ePWV的平均差值为6.45 m/s（95%一致性界限：1.24 - 11.7）。独立于心血管危险因素，ePWV与中国人群中的CVD及全因死亡率相关。
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