State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Small. 2021 Apr;17(16):e2004467. doi: 10.1002/smll.202004467. Epub 2021 Jan 15.
Recently, single-atom catalysts (SACs) have been receiving increasing attention in various catalytic fields, and meanwhile, emerging nanocatalytic medicine provides a novel tumor chemotherapy modality without using toxic chemodrugs. The distinct properties of SACs, such as well-defined and precisely located metal centers, identical coordination environment, tailorable composition and structure, and versatile functionality, make them promising candidates for catalytic tumor therapy. Herein, the most recent advances in nanocatalytic tumor therapy by using various types of SACs, especially their remarkable achievements in several nanocatalytic tumor therapy-based modalities, such as chemodynamic therapy by tumor microenvironment-responsive catalytic reactions, photodynamic therapy by photocatalytic reactions, sonodynamic therapy by sonocatalytic reactions, and parallel catalytic therapy by parallel catalytic reactions, are reviewed by focusing on the catalytic nanoplatform construction and catalytic mechanism. A concise but concentrated summary and outlook are provided finally to outline the perspectives and the remaining challenges for the future design and engineering of SACs for tumor therapy.
近年来，单原子催化剂（SACs）在各种催化领域受到越来越多的关注，同时，新兴的纳米催化医学为肿瘤化疗提供了一种新的模式，而无需使用有毒的化疗药物。SACs 的独特性质，如明确和精确定位的金属中心、相同的配位环境、可调节的组成和结构以及多功能性，使它们成为催化肿瘤治疗的有前途的候选者。本文重点介绍了各种类型的 SACs 在纳米催化肿瘤治疗中的最新进展，特别是它们在几种基于纳米催化肿瘤治疗的模式中的显著成就，如肿瘤微环境响应催化反应的化学动力学治疗、光催化反应的光动力治疗、声催化反应的声动力治疗以及平行催化反应的平行催化治疗，同时还关注了催化纳米平台的构建和催化机制。最后提供了一个简洁但集中的总结和展望，以概述未来设计和工程 SACs 用于肿瘤治疗的观点和剩余挑战。
