[不同类型干细胞治疗缺血性脑卒中的研究进展]
[Research progress of different types of stem cells in treatment of ischemic stroke].
作者信息
Chen Qiuzhu, Li Ling, Xie Huiqi
机构信息
Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021 Jan 15;35(1):111-117. doi: 10.7507/1002-1892.202004160.
OBJECTIVE
To review the recent research progress of different types of stem cells in the treatment of ischemic stroke.
METHODS
By searching the PubMed database, a systematic review had been carried out for the results of applying different types of stem cells in the treatment of ischemic stroke between 2000 and 2020.
RESULTS
Stem cells can be transplanted via intracranial, intravascular, cerebrospinal fluid, and intranasal route in the treatment of ischemic stroke. Paracrine and cell replacement are the two major mechanisms of the therapy. The researches have mainly focused on utilization of neural stem cells, embryonic stem cells, and mesenchymal stem cells. Each has its own advantages and disadvantages in terms of capability of migration, survival rate, and safety. Certain stem cell therapies have completed phase one clinical trial.
CONCLUSION
Stem cells transplantation is feasible and has a great potential for the treatment of ischemic stroke, albeit that certain obstacles, including the selection of stem cells, transplantation strategy, migration ability, survival rate, still wait to be solved.
目的
综述不同类型干细胞治疗缺血性脑卒中的近期研究进展。
方法
通过检索PubMed数据库，对2000年至2020年间应用不同类型干细胞治疗缺血性脑卒中的结果进行系统评价。
结果
干细胞可通过颅内、血管内、脑脊液和鼻内途径移植用于治疗缺血性脑卒中。旁分泌和细胞替代是该疗法的两个主要机制。研究主要集中在神经干细胞、胚胎干细胞和间充质干细胞的应用上。在迁移能力、存活率和安全性方面，每种干细胞都有其优缺点。某些干细胞疗法已完成一期临床试验。
结论
干细胞移植治疗缺血性脑卒中是可行的，且具有很大潜力，尽管仍有一些障碍有待解决，包括干细胞的选择、移植策略、迁移能力、存活率等。
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