Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300380, P.R. China.
Int J Mol Med. 2021 Mar;47(3). doi: 10.3892/ijmm.2021.4846. Epub 2021 Jan 15.
Radix Astragali (RA) is widely used in traditional Chinese medicine (TCM), and astragaloside IV (AS‑IV) is the most critical component of RA. Previous studies have demonstrated that AS‑IV exerts effects on the myocardium, nervous system and endocrine system, among others. In the present review article, data from studies conducted over the past 20 years were collated, which have evaluated the effects of AS‑IV on tumors. The mechanisms of action of AS‑IV on malignant cells both and were summarized and it was demonstrated that AS‑IV plays a vital role, particularly in inhibiting tumor growth and metastasis, promoting the apoptosis of tumor cells, enhancing immune function and preventing drug resistance. Moreover, AS‑IV controls several epithelial‑mesenchymal transformation (EMT)‑related and autophagy‑related pathways, such as the phosphoinositide‑3‑kinase (PI3K)/protein kinase B (AKT), Wnt/β‑catenin, mitogen‑activated protein kinase (MAPK)/extracellular regulated protein kinase (ERK) and transforming growth factor‑β (TGF‑β)/SMAD signaling pathways, which are commonly affected in the majority of tumors. The present review provides new perspectives on the functions of AS‑IV and its role as an adjuvant treatment in cancer chemotherapy.
黄芪（RA）在中药（TCM）中被广泛应用，其中黄芪甲苷（AS- IV）是 RA 最关键的成分。先前的研究表明，AS-IV 对心肌、神经系统和内分泌系统等均具有作用。在本综述文章中，整理了过去 20 年来关于 AS-IV 对肿瘤影响的研究数据。总结了 AS-IV 对恶性细胞的作用机制，结果表明 AS-IV 发挥了重要作用，特别是在抑制肿瘤生长和转移、促进肿瘤细胞凋亡、增强免疫功能和防止耐药性方面。此外，AS-IV 还控制着几个上皮-间充质转化（EMT）和自噬相关通路，如磷酸肌醇 3-激酶（PI3K）/蛋白激酶 B（AKT）、Wnt/β-连环蛋白、丝裂原活化蛋白激酶（MAPK）/细胞外调节蛋白激酶（ERK）和转化生长因子-β（TGF-β）/SMAD 信号通路，这些通路在大多数肿瘤中都普遍受到影响。本综述为 AS-IV 的功能及其在癌症化疗中的辅助治疗作用提供了新的视角。
