Department of Clinical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.
Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Vet Comp Oncol. 2021 Mar;19(1):61-68. doi: 10.1111/vco.12638. Epub 2020 Aug 26.
Fasting has been shown to decrease chemotherapy-associated adverse events (AEs), in part through insulin-like growth factor (IGF-1) reduction, and may induce a protective effect on normal cells during chemotherapy treatment in mice and people. The purpose of this study was to evaluate the effect of fasting on constitutional, bone marrow and gastrointestinal (GI) AEs, and serum glucose, IGF-1 and insulin levels in dogs receiving vincristine. The study was a prospective, crossover clinical trial in tumour-bearing dogs. Dogs were randomized to be fasted for 24 to 28 hours prior to and 6 hours following their first or second vincristine treatment, and fed normally for the alternate dose. A significant reduction in nausea, anorexia, lethargy and serum insulin was observed when dogs were fasted; however, no significant differences were found in other GI symptoms, neutrophil count, serum glucose or IGF-1. Fasting prior to vincristine therapy is a safe and effective treatment modality that helped mitigate constitutional and GI AEs in tumour-bearing dogs.
禁食已被证明可以减少化疗相关的不良反应（AEs），部分原因是胰岛素样生长因子（IGF-1）的减少，并且在小鼠和人类的化疗期间可能对正常细胞产生保护作用。本研究的目的是评估禁食对接受长春新碱治疗的犬的体质、骨髓和胃肠道（GI）不良反应以及血清葡萄糖、IGF-1 和胰岛素水平的影响。该研究是一项针对肿瘤犬的前瞻性、交叉临床试验。犬被随机分为两组，在第一次或第二次长春新碱治疗前禁食 24 至 28 小时，并在另一剂量时正常进食。当犬禁食时，观察到恶心、食欲不振、嗜睡和血清胰岛素显著减少；然而，其他 GI 症状、中性粒细胞计数、血清葡萄糖或 IGF-1 没有发现显著差异。在长春新碱治疗前禁食是一种安全有效的治疗方法，可以帮助减轻肿瘤犬的体质和胃肠道不良反应。
