Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Department of Internal and Integrative Medicine, Immanuel Krankenhaus Berlin, Berlin, Germany.
BMC Cancer. 2018 Apr 27;18(1):476. doi: 10.1186/s12885-018-4353-2.
This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer.
In an individually-randomized cross-over trial patients with gynecological cancer, 4 to 6 planned chemotherapy cycles were included. Thirty-four patients were randomized to STF in the first half of chemotherapies followed by normocaloric diet (group A;n = 18) or vice versa (group B;n = 16). Fasting started 36 h before and ended 24 h after chemotherapy (60 h-fasting period). QOL was assessed by the FACIT-measurement system.
The chemotherapy-induced reduction of QOL was less than the Minimally Important Difference (MID; FACT-G = 5) with STF but greater than the MID for non-fasted periods. The mean chemotherapy-induced deterioration of total FACIT-F was 10.4 ± 5.3 for fasted and 27.0 ± 6.3 for non-fasted cycles in group A and 14.1 ± 5.6 for non-fasted and 11.0 ± 5.6 for fasted cycles in group B. There were no serious adverse effects.
STF during chemotherapy is well tolerated and appears to improve QOL and fatigue during chemotherapy. Larger studies should prove the effect of STF as an adjunct to chemotherapy.
This trial was registered at clinicaltrials.gov: NCT01954836 .
本先导试验旨在研究短期禁食（STF）在妇科癌症患者化疗期间的可行性及其对生活质量（QOL）和幸福感的影响。
在一项个体随机交叉试验中，纳入了 4 至 6 个计划化疗周期的妇科癌症患者。34 名患者被随机分为化疗前半段进行 STF 组（A 组，n=18）或后半段进行 STF 组（B 组，n=16）。禁食从化疗前 36 小时开始，化疗后 24 小时结束（60 小时禁食期）。QOL 通过 FACIT 测量系统进行评估。
与非禁食期相比，STF 可减轻化疗引起的 QOL 降低，但低于最小有意义差异（MID；FACT-G=5）。与非禁食周期相比，A 组中禁食周期和非禁食周期的总 FACIT-F 评分化疗引起的恶化平均值分别为 10.4±5.3 和 27.0±6.3，B 组分别为 14.1±5.6 和 11.0±5.6。无严重不良事件。
化疗期间进行 STF 耐受良好，似乎可改善化疗期间的 QOL 和疲劳。更大规模的研究应证实 STF 作为化疗辅助治疗的效果。
本试验在 clinicaltrials.gov 上注册：NCT01954836。
