Warad Deepti M, Chattha Asma J, Rodriguez Vilmarie
Division of Pediatric Hematology-Oncology.
Special Coagulation Laboratory, Division of Hematopathology.
J Pediatr Hematol Oncol. 2021 Nov 1;43(8):e1124-e1127. doi: 10.1097/MPH.0000000000002053.
Venous thromboembolism (VTE) is a life-threatening complication rarely encountered with the use of combined oral contraceptives (COCs). Obesity is an additional thrombosis risk factor that has been shown to further increase the risk of VTE with the use of COCs. We present 5 cases of obese adolescents (body mass index >30 kg/m2) who encountered thrombosis complications while on COCs. Although the absolute risk of VTE events in the setting of COCs is rare, caution should be observed when choosing hormonal therapy and safer COCs alternatives discussed with adolescents who are obese.
静脉血栓栓塞症（VTE）是使用复方口服避孕药（COC）时很少遇到的一种危及生命的并发症。肥胖是另一个血栓形成风险因素，已证明它会进一步增加使用COC时发生VTE的风险。我们报告了5例肥胖青少年（体重指数>30 kg/m2）在服用COC期间发生血栓形成并发症的病例。尽管在使用COC的情况下发生VTE事件的绝对风险很低，但在选择激素治疗时应谨慎，并与肥胖青少年讨论更安全的COC替代方案。
