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[新冠后肺部后遗症:长期随访与管理]

[Post-COVID-19 pulmonary sequla: longterm follow up and management].

作者信息

Türktaş Haluk, Oğuzülgen İ Kıvılcım

机构信息

Department of Chest Diseases, Gazi University Faculty of Medicine, Ankara, Turkey.

出版信息

Tuberk Toraks. 2020 Dec;68(4):419-429. doi: 10.5578/tt.70353.

Abstract

Though it has been 8 months since the beginning of COVID-19 pandemic, number of cases and deaths are still seriously increasing. We still don't have enough evidence about the prognosis of patients who had COVID-19 pneumonia. In long term follow up we wonder if they will have rapid FVC decline, widespread fibrosis in computed tomography, loss in quality of life or increased mortality that we experience in idiopathic pulmonary fibrosis, chronic hypersensitivity pneumonia or autoimmune interstitial lung diseases. However, in elderly patients less severe dysfunction or non-progressive-fibrosis can cause morbidity and mortality. Therefore, if we consider millions of people who are affected by COVID-19, even a rare complication can cause serious health problem in social scale. Because of the importance of this issue randomized controlled trials should be rapidly planned on post-COVID fibrosis, COVID associated thrombosis, risk factors, prevention and treatment (1). In this review, the frequency, clinical importance, prevention and treatment of possible long-term sequels of COVID-19 pneumonia (pulmonary fibrosis, pulmonary embolism and pulmonary hypertension) will be discussed.

摘要

尽管自新冠疫情开始以来已有8个月,但病例数和死亡人数仍在急剧增加。我们仍没有足够的证据来了解新冠肺炎肺炎患者的预后情况。在长期随访中,我们想知道他们是否会像特发性肺纤维化、慢性过敏性肺炎或自身免疫性间质性肺疾病患者那样出现用力肺活量(FVC)迅速下降、计算机断层扫描显示广泛纤维化、生活质量下降或死亡率增加。然而,在老年患者中,不太严重的功能障碍或非进行性纤维化也可能导致发病和死亡。因此,如果我们考虑到数以百万计受新冠病毒影响的人,即使是一种罕见的并发症也可能在社会层面上引发严重的健康问题。鉴于这个问题的重要性,应该迅速针对新冠后纤维化、新冠相关血栓形成、危险因素、预防和治疗开展随机对照试验(1)。在这篇综述中,我们将讨论新冠肺炎肺炎可能的长期后遗症(肺纤维化、肺栓塞和肺动脉高压)的发生率、临床重要性、预防和治疗。

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