Department of Psychology, Temple University, Philadelphia, PA, USA.
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.
J Youth Adolesc. 2021 Apr;50(4):711-723. doi: 10.1007/s10964-020-01369-w. Epub 2021 Jan 15.
Chronic, systemic inflammation is implicated in physical and mental health; little is known about whether sex and racial differences detected in adulthood are observed during adolescence or about normative changes occurring during adolescence. This longitudinal, United States-based study examined four biomarkers of systemic inflammation [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and IL-8) in 315 adolescents (51% female; 58% black; baseline age = 16.49 years (SD = 1.56; range: 12.14-21.28)] at three timepoints. Notable results included: general decline in inflammatory biomarkers in older adolescents, lower levels of TNF-α/IL-8 in black adolescents, elevated CRP/IL-6 in females, and especially higher levels of IL-6 in black, female adolescents. Implications are discussed, particularly the potential health implications of elevated IL-6 in black females.
慢性全身性炎症与身心健康有关；人们对于在青春期是否会观察到成年期检测到的性别和种族差异，以及青春期期间是否会发生正常变化知之甚少。本项在美国开展的纵向研究在三个时间点检查了 315 名青少年（51%为女性；58%为黑人；基线年龄为 16.49 岁（SD=1.56；范围：12.14-21.28 岁）的四种全身炎症生物标志物[C 反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和白细胞介素-8（IL-8）]。值得注意的结果包括：年龄较大的青少年的炎症生物标志物普遍下降，黑人青少年的 TNF-α/IL-8 水平较低，女性的 CRP/IL-6 水平升高，而黑人、女性青少年的 IL-6 水平尤其高。讨论了其中的意义，特别是黑人女性中 IL-6 升高可能带来的健康影响。
