Department of Chemical Engineering, University of California, Davis, California 95616, USA.
Phys Rev Lett. 2020 Dec 31;125(26):268101. doi: 10.1103/PhysRevLett.125.268101.
We study hydrodynamic interactions and clustering mechanisms of active membrane inclusions within lipid bilayers. Pairs of inclusions display unique oscillatory dynamics that disappear when the 3D fluid adjacent to the membrane is confined. We reduce the governing equations to a coupled dynamical system whose phase behavior reveals the striking role of bulk confinement in enhancing cluster formation within the membrane. Using numerical simulations, we then extend this finding to demonstrate the role of confinement in controlling large-scale aggregation of membrane inclusions.
我们研究了活性膜包裹体在双层脂膜中的流体动力学相互作用和聚集机制。对包裹体的研究发现，当临近膜的 3D 流体被限制时，包裹体表现出独特的震荡动力学行为。我们将控制方程简化为一个耦合动力学系统，该系统的相位行为揭示了体相限制在增强膜内聚集体形成方面的显著作用。然后，我们使用数值模拟将这一发现扩展到证明限制在控制膜包裹体的大规模聚集中的作用。
