Nenning Karl-Heinz, Fösleitner Olivia, Schwartz Ernst, Schwarz Michelle, Schmidbauer Victor, Geisl Gudrun, Widmann Christian, Pirker Susanne, Baumgartner Christoph, Prayer Daniela, Pataraia Ekaterina, Bartha-Doering Lisa, Langs Georg, Kasprian Gregor, Bonelli Silvia B
Computational Imaging Research Lab, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Department of Biomedical Imaging and Image-guided Therapy, Division of Neuroradiology and Musculoskeletal Radiology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Clin Neurophysiol. 2021 Feb;132(2):404-411. doi: 10.1016/j.clinph.2020.10.031. Epub 2020 Dec 3.
To study hippocampal integration within task-positive and task-negative language networks and the impact of a diseased left and right hippocampus on the language connectome in temporal lobe epilepsy (TLE).
We used functional magnetic resonance imaging (fMRI) to study a homogenous group of 32 patients with TLE (17 left) and 14 healthy controls during a verb-generation task. We performed functional connectivity analysis and quantified alterations within the language connectome and evaluated disruptions of the functional dissociation along the anterior-posterior axis of the hippocampi.
Connectivity analysis revealed significant differences between left and right TLE compared to healthy controls. Left TLE showed widespread impairment of task-positive language networks, while right TLE showed less pronounced alterations. Particularly right TLE showed altered connectivity for cortical regions that were part of the default mode network (DMN). Left TLE showed a disturbed functional dissociation pattern along the left hippocampus to left and right inferior frontal language regions, while left and right TLE revealed an altered dissociation pattern along the right hippocampus to regions associated with the DMN.
Our results showed an impaired hippocampal integration into active language and the default mode networks, which both may contribute to language impairment in TLE.
Our results emphasize the direct role of the left hippocampus in language processing, and the potential role of the right hippocampus as a modulator between DMN and task-positive networks.
研究颞叶癫痫（TLE）患者任务阳性和任务阴性语言网络内的海马整合，以及左右海马病变对语言连接组的影响。
我们使用功能磁共振成像（fMRI）对32例TLE患者（17例左侧发病）和14名健康对照者在进行动词生成任务时进行研究。我们进行了功能连接分析，量化了语言连接组内的改变，并评估了沿海马前后轴功能分离的破坏情况。
连接性分析显示，与健康对照相比，左侧和右侧TLE之间存在显著差异。左侧TLE表现出任务阳性语言网络的广泛受损，而右侧TLE表现出的改变不太明显。特别是右侧TLE显示出作为默认模式网络（DMN）一部分的皮质区域的连接性改变。左侧TLE显示出沿左侧海马到左右额下回语言区域的功能分离模式紊乱，而左侧和右侧TLE均显示出沿右侧海马到与DMN相关区域的分离模式改变。
我们的结果表明海马整合到主动语言和默认模式网络中受损，这两者都可能导致TLE患者的语言障碍。
我们的结果强调了左侧海马在语言处理中的直接作用，以及右侧海马作为DMN和任务阳性网络之间调节者的潜在作用。
