CNRS (Centre National de la Recherche Scientifique), IGDR (Institut de Génétique et Développement de Rennes), UMR6290, University Rennes, F-35000 Rennes, France.
Department of Molecular Genetics and Genomics, Hospital University of Rennes (CHU Rennes), F-35000 Rennes, France.
Int J Mol Sci. 2021 Jan 13;22(2):752. doi: 10.3390/ijms22020752.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been shown to be an essential regulator of a broad spectrum of biological activities required for maintaining the body's vital functions. AhR also plays a critical role in tumorigenesis. Its role in cancer is complex, encompassing both pro- and anti-tumorigenic activities. Its level of expression and activity are specific to each tumor and patient, increasing the difficulty of understanding the activating or inhibiting roles of AhR ligands. We explored the role of AhR in tumor cell lines and patients using genomic data sets and discuss the extent to which AhR can be considered as a therapeutic target.
芳香烃受体 (AhR) 是一种配体激活的转录因子，已被证明是维持身体重要功能所需的广泛生物活性的必需调节剂。AhR 在肿瘤发生中也起着关键作用。它在癌症中的作用是复杂的，包括促肿瘤和抗肿瘤作用。其表达和活性水平因肿瘤和患者而异，这增加了理解 AhR 配体激活或抑制作用的难度。我们使用基因组数据集探讨了 AhR 在肿瘤细胞系和患者中的作用，并讨论了将 AhR 视为治疗靶点的程度。
