2(nd) Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Greece.
2(nd) Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Greece.
Maturitas. 2021 May;147:53-63. doi: 10.1016/j.maturitas.2020.11.004. Epub 2021 Jan 12.
Premature ovarian insufficiency (POI) refers to the loss of ovarian activity before the age of 40 years, which leads to hypoestrogenism and amenorrhoea. The diagnosis of POI in a young woman has potentially life-changing physical and emotional consequences for both the patient and her family. Therefore, it is very important that the diagnosis is correct and that it is made in a timely manner. Unfortunately, the diagnosis and therefore the effective treatment of POI are often delayed, which underlines the need for education of the broad medical community on the issue. A panel of menopause experts reviewed and critically appraised the literature, and present: 1) the diagnostic approach to POI, 2) the investigation of the etiology of this condition, 3) the therapeutic strategy regarding both hormone replacement therapy (HRT) and fertility and 4) the long-term follow-up and management for ensuring quality of life, as well as urogenital, cardiovascular, bone and mental health. The ultimate goal is to provide a complete toolkit for the primary care physician to have easy access to all the information needed for the optimal management of women with POI, in the context of evidence-based and personalized medicine.
卵巢早衰（POI）是指 40 岁以前卵巢活动丧失，导致雌激素缺乏和闭经。年轻女性 POI 的诊断会对患者及其家庭带来潜在的改变生活的身体和情感后果。因此，正确及时地做出诊断非常重要。不幸的是，POI 的诊断和有效治疗常常被延误，这凸显了对广大医学专业人员进行相关问题教育的必要性。一个更年期专家小组审查和批判性地评估了文献，并提出：1）POI 的诊断方法，2）该病症病因的研究，3）关于激素替代疗法（HRT）和生育的治疗策略，以及 4）长期随访和管理，以确保生活质量以及泌尿生殖、心血管、骨骼和心理健康。最终目标是为初级保健医生提供一个完整的工具包，以便在循证和个性化医学的背景下，轻松获得管理 POI 女性所需的所有信息。
