Gonzalez-Lima F, Velez D, Blanco R
Department of Anatomy, College of Medicine, Texas A&M University, College Station 77843.
Behav Neural Biol. 1988 Jan;49(1):74-82. doi: 10.1016/s0163-1047(88)91252-6.
The effects of the dopaminergic agonist bromocriptine (BC) and exogenously administered prolactin (PRL) on the spontaneous behavior of female cats were investigated. The objective was to test whether BC-induced behavioral effects may be antagonized by PRL. BC (6 mg/kg ip) administration induced abnormal behaviors such as limb flicks, abortive grooms, head/body shakes, and hallucinatory-like behavior/escape as well as excessive grooming. PRL (5 mg/kg ip) administration induced biphasic changes in grooming. The first change was an increase in grooming frequency averaging 256% of baseline control values and lasting for 1 h. This change was followed by reductions in grooming of 75 and 82.5% below baseline during Hours 2 and 3 postinjection, respectively. Combined BC and PRL treatment antagonized the frequency of BC-induced motor effects such as limb flicks, abortive grooms, and head/body shakes. Limb flicks occurred nine times more often 2 h after BC alone than after BC and PRL. The combined treatment also antagonized the excessive grooming observed after separate administrations of BC and PRL. The observed interactions between PRL and BC behavioral effects support the notion that PRL may be an important modulator of dopamine-dependent motor behavior in female cats.
研究了多巴胺能激动剂溴隐亭（BC）和外源性注射催乳素（PRL）对雌性猫自发行为的影响。目的是测试PRL是否可以拮抗BC诱导的行为效应。腹腔注射BC（6mg/kg）会诱发异常行为，如肢体轻弹、未完成的梳理动作、头部/身体摇晃、类似幻觉的行为/逃避以及过度梳理。腹腔注射PRL（5mg/kg）会导致梳理行为出现双相变化。第一个变化是梳理频率增加，平均为基线对照值的256%，持续1小时。随后在注射后第2小时和第3小时，梳理行为分别比基线减少75%和82.5%。BC和PRL联合治疗拮抗了BC诱导的运动效应的频率，如肢体轻弹、未完成的梳理动作和头部/身体摇晃。单独注射BC后2小时，肢体轻弹出现的频率比BC和PRL联合注射后高9倍。联合治疗还拮抗了单独注射BC和PRL后观察到的过度梳理行为。观察到的PRL和BC行为效应之间的相互作用支持了PRL可能是雌性猫多巴胺依赖性运动行为的重要调节因子这一观点。
