Gonzalez-Lima F, Stiehl W L, Medina R
Eur J Pharmacol. 1984 Jul 13;102(2):279-87. doi: 10.1016/0014-2999(84)90259-0.
The objective was to determine the behavioral effects and duration of action of bromocriptine (BC) doses from 6 to 60 mg/kg i.p. Cats were housed in large outdoors cages designed for prolonged observation using an ethological approach. Baseline behavior was measured after a 3 month period of habituation. The frequency of 12 behaviors was then scored continuously over 12 h following BC administration. Cats were also observed for one h at 24, 30, 36 and 48 h post-drug. The behavioral effects of BC were remarkably similar to those of LSD and psilocybin but lasted much longer. Treated cats showed hallucinatory-like and escape behavior. Abnormal involuntary movements such as limb flicks, abortive grooming, and head and body shakes were also evoked with a dose-dependent frequency. Lower doses (6-20) produced generalized arousal, but larger doses (30-60) resulted in a decrease in arousal. After 30 mg/kg, hallucinatory-like behavior and general activity (rubbing, treading, kneading) were high at 48 h post-drug, but there were no longer abnormal movements. Behavioral suppression followed the 60 mg/kg dose and peak effects were at 96 h post-injection. This model may prove useful to further study the neural basis of the psychoactive effects of BC.
目的是确定腹腔注射6至60毫克/千克剂量的溴隐亭（BC）的行为效应和作用持续时间。猫被安置在大型户外笼子里，采用行为学方法进行长时间观察。在3个月的适应期后测量基线行为。然后在给予BC后12小时内连续记录12种行为的频率。在给药后24、30、36和48小时也对猫进行1小时的观察。BC的行为效应与LSD和裸盖菇素非常相似，但持续时间长得多。接受治疗的猫表现出类似幻觉和逃避行为。还会引发异常的不自主运动，如肢体轻弹、未遂梳理以及头部和身体摇晃，其频率呈剂量依赖性。较低剂量（6 - 20）会引起全身兴奋，但较大剂量（30 - 60）会导致兴奋度降低。30毫克/千克给药后，48小时时类似幻觉的行为和一般活动（摩擦、踩踏、揉捏）较为明显，但不再有异常运动。给予60毫克/千克剂量后出现行为抑制，注射后96小时达到峰值效应。该模型可能对进一步研究BC精神活性作用的神经基础有用。
