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Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5.

作者信息

Lei Li, Yan Bei, Liu Panpan, Li Jie, Chen Chao, Zhu Wu, Kuang Yehong, Chen Xiang, Peng Cong

机构信息

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China.

出版信息

Signal Transduct Target Ther. 2021 Jan 15;6(1):19. doi: 10.1038/s41392-020-00379-1.

DOI:10.1038/s41392-020-00379-1
PMID:33452232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7810744/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d68/7810744/0fa92b8336c5/41392_2020_379_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d68/7810744/0fa92b8336c5/41392_2020_379_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d68/7810744/0fa92b8336c5/41392_2020_379_Fig1_HTML.jpg

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本文引用的文献

1
Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis.脂质组学分析揭示了甘油磷脂代谢在银屑病中的作用。
Gigascience. 2017 Oct 1;6(10):1-11. doi: 10.1093/gigascience/gix087.
2
Autotaxin Is Regulated by Glucose and Insulin in Adipocytes.自分泌运动因子在脂肪细胞中受葡萄糖和胰岛素调控。
Endocrinology. 2017 Apr 1;158(4):791-803. doi: 10.1210/en.2017-00035.
3
Immunology of psoriasis.银屑病的免疫学
中药湿痹满通过抑制IL-23/Th17轴和CXCL16介导的内皮细胞活化来改善银屑病。
Chin Med. 2024 Mar 1;19(1):38. doi: 10.1186/s13020-024-00907-z.
4
Signaling pathways and targeted therapies for psoriasis.银屑病的信号通路和靶向治疗。
Signal Transduct Target Ther. 2023 Nov 27;8(1):437. doi: 10.1038/s41392-023-01655-6.
5
A Solid-Phase Microextraction-Liquid Chromatography-Mass Spectrometry Method for Analyzing Serum Lipids in Psoriatic Disease.一种用于分析银屑病患者血清脂质的固相微萃取-液相色谱-质谱法
Metabolites. 2023 Aug 20;13(8):963. doi: 10.3390/metabo13080963.
6
Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis.纳曲昔林通过抑制磷脂酶 A2 和调节磷脂代谢来改善银屑病样皮炎。
Front Immunol. 2023 Jan 4;13:1094375. doi: 10.3389/fimmu.2022.1094375. eCollection 2022.
7
Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implications.1 型糖尿病中的脂代谢：发病机制和治疗意义。
Front Immunol. 2022 Oct 6;13:999108. doi: 10.3389/fimmu.2022.999108. eCollection 2022.
8
Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway.溶血磷脂酸通过 LPAR1/ROCK2/PI3K/AKT 信号通路促进角质形成细胞增殖介导咪喹莫特诱导的银屑病样症状。
Int J Mol Sci. 2021 Oct 5;22(19):10777. doi: 10.3390/ijms221910777.
Annu Rev Immunol. 2014;32:227-55. doi: 10.1146/annurev-immunol-032713-120225.
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LPA receptor signaling: pharmacology, physiology, and pathophysiology.溶血磷脂酸受体信号传导：药理学、生理学及病理生理学
J Lipid Res. 2014 Jul;55(7):1192-214. doi: 10.1194/jlr.R046458. Epub 2014 Mar 18.
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EMBO J. 2003 Jan 2;22(1):109-20. doi: 10.1093/emboj/cdg009.