Sipponen P, Varis K, Cederberg A, Salmi H A, Seppälä K, Ihamäki T, Kosunen T U
Department of Pathology, Jorvi Hospital, Espoo, Finland.
APMIS. 1988 Jan;96(1):84-8. doi: 10.1111/j.1699-0463.1988.tb05272.x.
Campylobacter pylori is supposed to be involved in the pathogenesis of gastroduodenal peptic ulcer diseases and chronic gastritis. In order to study whether the Campylobacter pylori in the stomach of peptic ulcer patients is related to ulcer itself or to a co-existing chronic gastritis, we examined the frequency of the bacteria in Giemsa stained histological sections of biopsy specimens from a series of patients with active peptic ulcer and from series of non-ulcer control subjects. We found no difference in the frequency of Campylobacter- positive cases between ulcer patients and non-ulcer controls when the comparison was done within the same category of chronic gastritis; e.g., within the category of chronic superficial gastritis 74% and 78% of cases showed the bacteria in antral biopsies from ulcer patients and from non-ulcer controls, respectively. In both ulcer patients and control subjects, in similar way in both antral and body mucosa, the Campylobacter pylori was strongly associated with chronic superficial gastritis but was more weakly associated with chronic atrophic gastritis, and the bacteria were only occasionally seen in normal mucosa. We conclude that Campylobacter pylori is associated with chronic gastritis in peptic ulcer patients but is not related to active ulcer.
幽门螺杆菌被认为与胃十二指肠消化性溃疡疾病和慢性胃炎的发病机制有关。为了研究消化性溃疡患者胃内的幽门螺杆菌是与溃疡本身相关还是与并存的慢性胃炎相关，我们检查了一系列活动性消化性溃疡患者以及一系列非溃疡对照受试者活检标本的吉姆萨染色组织切片中该细菌的检出频率。当在同一类慢性胃炎中进行比较时，我们发现溃疡患者和非溃疡对照之间幽门螺杆菌阳性病例的频率没有差异；例如，在慢性浅表性胃炎类别中，溃疡患者和非溃疡对照的胃窦活检标本中分别有74%和78%的病例显示有该细菌。在溃疡患者和对照受试者中，无论在胃窦还是胃体黏膜，幽门螺杆菌都与慢性浅表性胃炎密切相关，但与慢性萎缩性胃炎的相关性较弱，且在正常黏膜中仅偶尔可见该细菌。我们得出结论，幽门螺杆菌与消化性溃疡患者的慢性胃炎有关，但与活动性溃疡无关。
