Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia.
Research Institute - S. V. Ochapovsky Krasnodar Regional Clinical Hospital No. 1, Ministry of Health of Krasnodar Krai, Krasnodar, Russia.
Bull Exp Biol Med. 2021 Jan;170(3):378-383. doi: 10.1007/s10517-021-05071-0. Epub 2021 Jan 16.
The tissue reaction of pig skin to implantation of decellularized and recellularized dermal matrices on a formed wound defect was evaluated by histological methods on days 2, 5, 8, 16, and 20 after surgery. Differences in tissue response to different matrices were identified. In experimental wounds coated with decellularized dermal matrices, we observed the formation of a scar tissue, which required autodermoplasty on day 12 of the experiment. In wounds coated with recellularized dermal matrices, all layers of the skin completely recovered by day 20 after surgery with the formation of full dermal and epidermal layers. Our findings suggest that reparative morphological changes in the wound depend on the presence of fibroblasts in the implanted dermal matrix.
通过组织学方法评价猪皮对脱细胞和再细胞真皮基质在形成的创伤缺损处植入的组织反应，术后第 2、5、8、16 和 20 天进行评估。鉴定了不同基质对组织反应的差异。在涂有脱细胞真皮基质的实验性伤口中，我们观察到形成了瘢痕组织，在实验的第 12 天需要进行自体植皮。在涂有再细胞真皮基质的伤口中，手术后 20 天所有皮肤层完全恢复，形成完整的真皮和表皮层。我们的研究结果表明，创面的修复形态变化取决于植入真皮基质中纤维母细胞的存在。
