Burn Treatment Center, Percy Military Hospital, Clamart, France.
Cell Prolif. 2011 Apr;44 Suppl 1(Suppl 1):48-54. doi: 10.1111/j.1365-2184.2010.00727.x.
Severe burns remain a life-threatening local and general inflammatory condition often with serious sequelae, despite remarkable progress in their treatment over the past three decades. Cultured epidermal autografts, the first and still most up-to-date cell therapy for burns, plays a key role in that progress, but drawbacks to this need to be reduced by using cultured dermal-epidermal substitutes. This review focuses on what could be, in our view, the next major breakthrough in cell therapy of burns - use of mesenchymal stromal cells (MSCs). After summarizing current knowledge, including our own clinical experience with MSCs in the pioneering field of cell therapy of radiation-induced burns, we discuss the strong rationale supporting potential interest in MSCs in treatment of thermal burns, including limited but promising pre-clinical and clinical data in wound healing and acute inflammatory conditions other than burns. Practical options for future therapeutic applications of MSCs for burns treatment, are finally considered.
严重烧伤仍然是一种危及生命的局部和全身炎症性疾病，尽管在过去三十年中在治疗方面取得了显著进展，但仍存在严重的后遗症。表皮细胞培养自体移植物是烧伤治疗的第一种也是迄今为止最新的细胞疗法，在这一进展中发挥了关键作用，但需要通过使用培养的皮肤-表皮替代物来减少这种疗法的缺点。这篇综述重点介绍了我们认为在烧伤细胞治疗方面的下一个重大突破——间充质基质细胞（MSCs）的应用。在总结了目前的知识，包括我们自己在细胞治疗辐射诱导烧伤领域的 MSC 临床经验后，我们讨论了支持在治疗热烧伤中使用 MSC 的强有力的基本原理，包括在伤口愈合和除烧伤以外的急性炎症性疾病方面有限但有前途的临床前和临床数据。最后还考虑了用于烧伤治疗的 MSC 的未来治疗应用的实际选择。
