利用机械生物学进行组织工程。
Harnessing Mechanobiology for Tissue Engineering.
机构信息
Department of Biomedical Engineering and the Biological Design Center, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
Department of Biomedical Engineering and the Biological Design Center, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
出版信息
Dev Cell. 2021 Jan 25;56(2):180-191. doi: 10.1016/j.devcel.2020.12.017. Epub 2021 Jan 15.
A primary challenge in tissue engineering is to recapitulate both the structural and functional features of whole tissues and organs. In vivo, patterning of the body plan and constituent tissues emerges from the carefully orchestrated interactions between the transcriptional programs that give rise to cell types and the mechanical forces that drive the bending, twisting, and extensions critical to morphogenesis. Substantial recent progress in mechanobiology-understanding how mechanics regulate cell behaviors and what cellular machineries are responsible-raises the possibility that one can begin to use these insights to help guide the strategy and design of functional engineered tissues. In this perspective, we review and propose the development of different approaches, from providing appropriate extracellular mechanical cues to interfering with cellular mechanosensing machinery, to aid in controlling cell and tissue structure and function.
组织工程面临的一个主要挑战是重现整个组织和器官的结构和功能特征。在体内，体形规划和组成组织的模式形成源于导致细胞类型的转录程序与驱动对形态发生至关重要的弯曲、扭曲和伸展的机械力之间的精心协调的相互作用。机械生物学方面的重大进展——理解力学如何调节细胞行为以及哪些细胞机制负责——使得人们有可能开始利用这些见解来帮助指导功能性工程组织的策略和设计。在这个观点中，我们回顾并提出了不同方法的发展，从提供适当的细胞外机械线索到干扰细胞的机械感觉机制，以帮助控制细胞和组织的结构和功能。
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