神经发育的力学生物学。
Mechanobiology of neural development.
机构信息
Department of Physiology & Biophysics, UC Irvine, Irvine, CA, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA, USA.
Department of Physiology & Biophysics, UC Irvine, Irvine, CA, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA, USA; Center for Complex Biological Systems, UC Irvine, Irvine, CA, USA; Department of Biomedical Engineering, UC Irvine, Irvine, CA, USA.
出版信息
Curr Opin Cell Biol. 2020 Oct;66:104-111. doi: 10.1016/j.ceb.2020.05.012. Epub 2020 Jul 17.
As the brain develops, proliferating cells organize into structures, differentiate, migrate, extrude long processes, and connect with other cells. These biological processes produce mechanical forces that further shape cellular dynamics and organ patterning. A major unanswered question in developmental biology is how the mechanical forces produced during development are detected and transduced by cells to impact biochemical and genetic programs of development. This gap in knowledge stems from a lack of understanding of the molecular players of cellular mechanics and an absence of techniques for measuring and manipulating mechanical forces in tissue. In this review article, we examine recent advances that are beginning to clear these bottlenecks and highlight results from new approaches that reveal the role of mechanical forces in neurodevelopmental processes.
随着大脑的发育，增殖细胞会组织成结构，分化，迁移，伸出长的突起，并与其他细胞连接。这些生物过程会产生机械力，从而进一步塑造细胞动力学和器官模式。发育生物学中的一个主要未解决的问题是，发育过程中产生的机械力如何被细胞检测和转导，从而影响发育的生化和遗传程序。这种知识上的差距源于对细胞力学的分子参与者的理解不足，以及缺乏测量和操纵组织中机械力的技术。在这篇综述文章中，我们考察了最近的一些进展，这些进展开始清除这些瓶颈，并强调了新方法的结果，这些结果揭示了机械力在神经发育过程中的作用。
Zotero 插件