评估和改进学术型筛选文库：圣裘德方法。
Evaluating and evolving a screening library in academia: the St Jude approach.
机构信息
Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
出版信息
Drug Discov Today. 2021 Apr;26(4):1060-1069. doi: 10.1016/j.drudis.2021.01.005. Epub 2021 Jan 14.
Abstract
The quality of lead compounds is a key factor for determining the success of chemical probe and drug discovery programs. Given that high-throughput screening (HTS) continues to be a dominant lead generation paradigm, access to high-quality screening libraries is crucial for such efforts in both industry and academia. Here, we discuss the strategy implemented a decade ago to build from scratch one of the largest compound collections in academia, containing ∼575 000 carefully annotated small molecules, and a recent multidisciplinary effort designed to further enhance the collection to meet our research demands for the next decade.
摘要
化合物的质量是决定化学探针和药物发现项目成功的关键因素。鉴于高通量筛选（HTS）仍然是一种主要的先导化合物生成方法，因此，对于工业界和学术界来说，获得高质量的筛选库对于这些努力至关重要。在这里，我们将讨论十年前实施的策略，该策略从零开始构建了学术界最大的化合物集合之一，其中包含约 575000 种经过精心注释的小分子化合物，以及最近的多学科努力，旨在进一步增强该集合，以满足我们未来十年的研究需求。
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