Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Anal Chim Acta. 2021 Feb 1;1144:158-174. doi: 10.1016/j.aca.2020.10.007. Epub 2020 Oct 10.
Paper-based analytical devices possess desirable properties such as low cost, convenient production, and rapid output. These advantages over conventional analytical devices have attracted tremendous attention in recent years, and an abundance of fabrication techniques have been achieved with different designs. Related approaches are adopted by scientists and engineers from different research fields to create practical devices tailored for various applications. Among a diverse selection of strategies, paper-based analytical devices featuring enclosed channels can protect its contents from environmental harm, which is helpful in designing paper-based devices aimed toward practical use. However, superior properties of enclosed device designs have often been neglected when a paper-based platform is selected, and related discussion is still lacking in the field. To fill this empty space in the relevant literature, important issues are highlighted and recent research achievements are included in this article, which should have implication for scientists interested in sensing technology, analytical chemistry, material science, and miniaturized devices. For the convenience of reader's understanding, this article provides a general introduction to the basic properties and concepts of paper-based analytical devices. Firstly, commonly used fabrication strategies and detection methods are mentioned, with an in-depth emphasis on paper-based devices with enclosed channels, including breakthroughs in device types, thoughts on novel fabrication, and practical application examples. Subsequently, other important topics related to enclosed paper-based device design are summarized, and future challenges and opportunities in the field are also discussed.
基于纸张的分析器件具有成本低、制作方便、快速输出等优点。这些相对于传统分析器件的优势近年来引起了极大的关注，并且已经采用了多种设计的丰富制造技术。来自不同研究领域的科学家和工程师采用相关方法来创建针对各种应用的实用设备。在各种策略中，具有封闭通道的基于纸张的分析器件可以保护其内容物免受环境伤害，这有助于设计针对实际用途的基于纸张的器件。然而，在选择基于纸张的平台时，通常忽略了封闭器件设计的优越特性，并且该领域仍然缺乏相关讨论。为了填补相关文献中的空白，本文强调了重要问题并包括了最近的研究成果，这对于对传感技术、分析化学、材料科学和小型化设备感兴趣的科学家应该具有启示意义。为了方便读者理解，本文对基于纸张的分析器件的基本性质和概念进行了概述。首先，提到了常用的制造策略和检测方法，并深入探讨了具有封闭通道的基于纸张的器件，包括器件类型的突破、新型制造思路和实际应用实例。随后，总结了与封闭基于纸张的器件设计相关的其他重要主题，并讨论了该领域未来的挑战和机遇。
