Sara S J, Devauges V
Département de Psychophysiologie, C.N.R.S., Gif-sur-Yvette, France.
Brain Res. 1988 Jan 12;438(1-2):299-303. doi: 10.1016/0006-8993(88)91351-0.
Rats were trained to run a linear maze for food reinforcement. During the 5-week retention interval, they were implanted under electrophysiological control with fine stimulating electrodes aimed at the nucleus locus coeruleus (LC). When tested 5 weeks after training, control rats showed forgetting in that they made significantly more errors at the test trial than at the last training trial. Low-level stimulation of LC immediately before the test alleviated the forgetting in that this group made significantly fewer errors than the non-stimulated group on two successive days. The results are taken as behavioral evidence of a role for noradrenergic projections from LC in memory and attention.
大鼠经过训练，在直线迷宫中奔跑以获取食物奖励。在为期5周的保持期内，在电生理控制下，将精细的刺激电极植入大鼠体内，电极瞄准蓝斑核（LC）。训练5周后进行测试时，对照大鼠表现出遗忘现象，即在测试试验中犯的错误明显多于最后一次训练试验。在测试前立即对LC进行低水平刺激减轻了遗忘，因为该组在连续两天内犯的错误明显少于未受刺激的组。这些结果被视为LC去甲肾上腺素能投射在记忆和注意力中起作用的行为证据。
