Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
Department of Emergency, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
Life Sci. 2021 Mar 15;269:119044. doi: 10.1016/j.lfs.2021.119044. Epub 2021 Jan 15.
Acute lung inflammatory diseases severely affect the patients' recovery and outcomes worldwide. Unregulated acute inflammatory response is fundamentally central to acute lung inflammation including acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To limit the potentially deleterious effects of acute lung inflammation, complex transcriptional and posttranscriptional regulatory networks have been explored, which often involves long noncoding RNAs (lncRNA). LncRNAs are RNAs that longer than 200 nucleotides, functioning as scaffolds or decoys in the cytoplasm or nucleus. By now, lncRNAs have been found to join in all major cellular processes including cell proliferation, metabolism, stress response or death. Extensive advance over the last decade furthermore indicated a fundamental role of lncRNAs in acute lung inflammation. This article reviews and summarizes the current knowledge on lncRNA in acute lung inflammatory response.
急性肺炎症性疾病在全球范围内严重影响患者的康复和预后。未调节的急性炎症反应是急性肺炎症包括急性肺损伤 (ALI) 和急性呼吸窘迫综合征 (ARDS) 的核心。为了限制急性肺炎症的潜在有害影响，已经探索了复杂的转录和转录后调节网络，其中通常涉及长非编码 RNA (lncRNA)。lncRNA 是长度大于 200 个核苷酸的 RNA，在细胞质或细胞核中充当支架或诱饵。到目前为止，已经发现 lncRNA 参与了包括细胞增殖、代谢、应激反应或死亡在内的所有主要细胞过程。过去十年的广泛进展进一步表明，lncRNA 在急性肺炎症中起着基础性作用。本文综述并总结了 lncRNA 在急性肺炎症反应中的最新知识。
