大鼠顶叶皮层刺激引起的皮层和丘脑葡萄糖代谢降低。

Decreases of cortical and thalamic glucose metabolism produced by parietal cortex stimulation in the rat.

作者信息

Sharp J W, Gonzalez M F, Morton M T, Simon R P, Sharp F R

机构信息

Department of Neurology, University of California, San Francisco.

出版信息

Brain Res. 1988 Jan 12;438(1-2):357-62. doi: 10.1016/0006-8993(88)91363-7.

DOI:10.1016/0006-8993(88)91363-7

PMID:3345443

Abstract

Parietal cortex stimulation elicited focal decreases as well as increases of brain glucose metabolism in ipsilateral cortex, ipsilateral thalamus, and contralateral cortex of rats in a pattern resembling 'surround inhibition'. It is proposed that parietal stimulation activated inhibitory circuits which decreased cortical and thalamic glucose metabolism. This decrease of cerebral glucose metabolism is important for interpreting brain glucose metabolic studies particularly when metabolic changes do not correlate with changes of neuronal activity.

摘要

顶叶皮层刺激在大鼠的同侧皮层、同侧丘脑和对侧皮层引发了脑葡萄糖代谢的局灶性降低以及升高，其模式类似于“周围抑制”。有人提出，顶叶刺激激活了抑制性回路，从而降低了皮层和丘脑的葡萄糖代谢。脑葡萄糖代谢的这种降低对于解释脑葡萄糖代谢研究非常重要，特别是当代谢变化与神经元活动的变化不相关时。