Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Sheffield, UK.
Department of Infection, Immunity & Cardiovascular Diseases, University of Sheffield, Sheffield, UK.
Diagn Microbiol Infect Dis. 2021 May;100(1):115305. doi: 10.1016/j.diagmicrobio.2020.115305. Epub 2021 Jan 6.
This study aims to identify factors associated with duration of intravenous (IV) and follow-on oral antibiotic therapy for cellulitis in patients treated through outpatient parenteral antimicrobial therapy (OPAT). A retrospective review of episodes of cellulitis treated over a year (January 2018-January 2019) at a large teaching hospital in Sheffield, UK. Overall, 292 OPAT episodes of cellulitis were reviewed. The mean durations of IV therapy and follow-on oral antibiotics were 5.3 days (range 1-32 days) and 6.1 days (range 2-17 days), respectively. Age, peak C-reactive protein and frequency of medical assessments during OPAT were independently associated with longer duration of IV therapy. Senior clinicians were likely to prescribe shorter courses of follow-on oral antibiotics. IV to oral conversion was more likely to occur on the first day of the work week. Our findings suggest that clinical and OPAT-related factors can influence early conversion to oral antibiotic therapy.
本研究旨在确定与门诊静脉输注抗菌药物治疗（outpatient parenteral antimicrobial therapy，OPAT）患者蜂窝织炎静脉（IV）和后续口服抗生素治疗持续时间相关的因素。对英国谢菲尔德一家大型教学医院一年（2018 年 1 月至 2019 年 1 月）期间治疗的蜂窝织炎发作进行回顾性分析。共回顾了 292 例 OPAT 蜂窝织炎发作。IV 治疗和后续口服抗生素的平均持续时间分别为 5.3 天（范围为 1-32 天）和 6.1 天（范围为 2-17 天）。年龄、峰值 C 反应蛋白和 OPAT 期间的医疗评估频率与 IV 治疗时间的延长独立相关。资深临床医生可能会开较短疗程的后续口服抗生素。IV 到口服的转换更有可能在工作周的第一天发生。我们的研究结果表明，临床和 OPAT 相关因素可能会影响早期转为口服抗生素治疗。
