从海蓬子（Limonium gmelinii（Willd.）Kuntze）的根部分离得到的木脂酰胺及其抗糖尿病、细胞毒性和抗炎活性。
Lignanamides from the roots of Limonium gmelinii (Willd.) Kuntze and their anti-diabetic, cytotoxic and anti-inflammatory activities.
机构信息
The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100039, PR China.
The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China.
出版信息
Phytochemistry. 2021 Apr;184:112648. doi: 10.1016/j.phytochem.2020.112648. Epub 2021 Jan 14.
Nine undescribed lignanamides, limoniumins A-I, together with ten known lignanamides and two known phenolics were isolated from ethyl acetate extract of the roots of Limonium gmelinii (Plumbaginaceae). Their structures were determined by spectroscopic analysis including 1D and 2D NMR and HRESIMS experiments. Limoniumin A is the first hybrid lignanamide of phenylpropanoid and coumarin. All tested lignanamides showed significant inhibitory activity against α-glucosidase stronger than positive control and remarkable inhibitory effect to PTP1B with IC values less than 10 μM. In addition, some lignanamides exhibited moderate cytotoxic activity against HeLa and MCF-7 cells and anti-inflammatory activity against COX-2 in a dose-dependent way.
从甘西鼠尾草（紫草科）根的乙酸乙酯提取物中分离得到了九种未描述的木质酰胺，即 limoniumins A-I，以及十种已知的木质酰胺和两种已知的酚类化合物。通过包括 1D 和 2D NMR 和 HRESIMS 实验在内的光谱分析确定了它们的结构。Limoniumin A 是苯丙素和香豆素的第一个杂交木质酰胺。所有测试的木质酰胺对 α-葡萄糖苷酶的抑制活性均强于阳性对照，对 PTP1B 的抑制作用显著，IC 值均小于 10 μM。此外，一些木质酰胺对 HeLa 和 MCF-7 细胞表现出中等的细胞毒性活性，并以剂量依赖的方式表现出对 COX-2 的抗炎活性。
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