荜茇酰胺类化合物从 Piper hancei maxim 的茎和他们的抗炎和细胞毒性活性。
Lignanamides from the stems of Piper hancei maxim. and their anti-inflammatory and cytotoxic activities.
机构信息
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
College of Life and Health Sciences, Northeastern University, Shenyang 110819, People's Republic of China.
出版信息
Fitoterapia. 2022 Sep;161:105231. doi: 10.1016/j.fitote.2022.105231. Epub 2022 Jun 11.
Four new lignanamides, hancamides A - D (1-4), together with four known analogs (5-8), were isolated from the stems of Piper hancei Maxim. Their structures were determined based on 1D and 2D NMR, IR, UV, and HR-ESIMS spectroscopic analysis as well as by comparison with the reported data. All the isolates exhibited potential inhibitory effects on NO production in LPS-induced BV-2 microglial cells, with IC values of 4.26-40.68 μM. Moreover, compounds 2 and 8 displayed moderate cytotoxic activities against MGC-803, HepG2, SKOV-3, T24, and HeLa cells, with IC values ranging from 13.57 to 34.20 μM, respectively.
从 Piper hancei Maxim 的茎中分离得到了四个新的木脂酰胺，汉酰胺 A-D（1-4），以及四个已知的类似物（5-8）。根据 1D 和 2D NMR、IR、UV 和 HR-ESIMS 光谱分析以及与报道数据的比较，确定了它们的结构。所有分离物均显示出对 LPS 诱导的 BV-2 小胶质细胞中 NO 产生的潜在抑制作用，IC 值为 4.26-40.68 μM。此外，化合物 2 和 8 对 MGC-803、HepG2、SKOV-3、T24 和 HeLa 细胞表现出中等的细胞毒性活性，IC 值范围分别为 13.57-34.20 μM。
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