Epigenomics, Proliferation and the Identity of Cells, Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS, UMR3738, Paris, France.
Epigenomics, Proliferation and the Identity of Cells, Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS, UMR3738, Paris, France.
Curr Opin Cell Biol. 2021 Apr;69:41-47. doi: 10.1016/j.ceb.2020.12.009. Epub 2021 Jan 14.
When cells enter mitosis, they undergo series of dramatic changes in their structure and function that severely hamper gene regulatory processes and gene transcription. This raises the question of how daughter cells efficiently recapitulate the gene expression profile of their mother such that cell identity can be preserved. Here, we review recent evidence supporting the view that distinct chromatin-associated mechanisms of gene-regulatory inheritance assist daughter cells in the postmitotic reestablishment of gene activity with increased fidelity.
当细胞进入有丝分裂时，它们的结构和功能会发生一系列剧烈的变化，严重阻碍基因调控过程和基因转录。这就提出了一个问题，即子细胞如何有效地再现其母细胞的基因表达谱，从而保持细胞的身份。在这里，我们回顾了最近的证据，支持这样一种观点，即不同的染色质相关的基因调控遗传机制有助于子细胞在后有丝分裂阶段以更高的保真度重新建立基因活性。
