主观执行功能在有主观认知下降和 MCI 的老年人中的稳定性。
Stability of Subjective Executive Functioning in Older Adults with aMCI and Subjective Cognitive Decline.
机构信息
VA Maryland Health Care System, Baltimore, MD 21201, USA.
Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
出版信息
Arch Clin Neuropsychol. 2021 Aug 31;36(6):1012-1018. doi: 10.1093/arclin/acaa129.
OBJECTIVE
Subjective memory concerns are characteristic of individuals with amnestic mild cognitive impairment (aMCI) and subjective cognitive decline (SCD), though subjective changes in executive functions have also been reported. In a cohort study, we examined the temporal stability of subjective report of executive functioning in a high education (mean = 16.8 years) sample of cognitively normal (CN) older adults and those with aMCI or SCD.
METHOD
Participants (CN, n = 22; aMCI, n = 21; SCD, n = 24) and their informants completed the BRIEF-A and neuropsychological tests at two time points separated by approximately 1 year.
RESULTS
Analyses focused on those with diagnostic stability (95.7%). Participants with aMCI and SCD, and their informants, endorsed worse executive functions relative to CN at both time points. No group by time interaction was observed for subjective or objective measures of executive function.
CONCLUSIONS
Diagnostically stable CN older adults, and those with prodromal dementia conditions, report stable executive functioning at 1-year follow-up.
目的
遗忘型轻度认知障碍（aMCI）和主观认知下降（SCD）患者的特征是出现主观记忆问题，但也有研究报告称执行功能出现主观变化。在一项队列研究中，我们研究了认知正常（CN）老年人和 aMCI 或 SCD 患者中执行功能的主观报告在高教育（平均= 16.8 年）样本中的时间稳定性。
方法
参与者（CN，n=22；aMCI，n=21；SCD，n=24）及其知情人在大约 1 年的时间内两次完成 BRIEF-A 和神经心理学测试。
结果
分析集中在诊断稳定的参与者上（95.7%）。在两个时间点，aMCI 和 SCD 患者及其知情人相对于 CN 报告的执行功能更差。在主观或客观的执行功能测量中，没有观察到组与时间的交互作用。
结论
在 1 年的随访中，诊断稳定的 CN 老年人和处于痴呆前期的患者报告执行功能稳定。
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