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使用机器人放射外科系统开发光栅扫描调强放疗。

Development of raster scanning IMRT using a robotic radiosurgery system.

机构信息

Miyakojima IGRT Clinic, Miyakojima-ku, Osaka 534-0021, Japan.

Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

出版信息

J Radiat Res. 2021 Mar 10;62(2):364-373. doi: 10.1093/jrr/rraa136.

Abstract

Treatment time with the CyberKnife frameless radiosurgery system is prolonged due to the motion of the robotic arm. We have developed a novel scanning irradiation method to reduce treatment time. We generated treatment plans mimicking eight-field intensity-modulated radiotherapy (IMRT) plans generated for the Novalis radiosurgery system. 2D dose planes were generated with multiple static beam spots collimated by a fixed circular cone. The weights of the uniformly distributed beam spots in each dose plane were optimized using the attraction-repulsion model. The beam spots were converted to the scanning speed to generate the raster scanning plan. To shorten treatment time, we also developed a hybrid scanning method which combines static beams with larger cone sizes and the raster scanning method. Differences between the Novalis and the scanning plan's dose planes were evaluated with the criterion of a 5% dose difference. The mean passing rates of three cases were > 85% for cone sizes ≤ 12.5 mm. Although the total monitor units (MU) increased for smaller cone sizes in an inverse-square manner, the hybrid scanning method greatly reduced the total MU, while maintaining dose distributions comparable to those with the Novalis plan. The estimated treatment time of the hybrid scanning with a 12.5 mm cone size was on average 22% shorter than that of the sequential plans. This technique will be useful in allowing the CyberKnife with conventional circular cones to achieve excellent dose distribution with a shortened treatment time.

摘要

由于机器人手臂的运动,使用 CyberKnife 无框架放射外科系统治疗的时间会延长。我们开发了一种新的扫描照射方法来缩短治疗时间。我们生成了模拟 Novalis 放射外科系统生成的八野强度调制放射治疗(IMRT)计划的治疗计划。使用吸引-排斥模型对多个由固定圆锥准直的静态射束点生成的 2D 剂量平面进行了优化。将均匀分布的射束点的权重转换为扫描速度,以生成光栅扫描计划。为了缩短治疗时间,我们还开发了一种混合扫描方法,该方法将静态射束与较大的圆锥尺寸和光栅扫描方法相结合。使用 5%剂量差异的标准评估 Novalis 和扫描计划的剂量平面之间的差异。对于圆锥尺寸≤12.5mm 的三种情况,通过率均>85%。尽管对于较小的圆锥尺寸,总监测单位(MU)以平方反比的方式增加,但混合扫描方法大大减少了总 MU,同时保持与 Novalis 计划相当的剂量分布。使用 12.5mm 圆锥尺寸的混合扫描的估计治疗时间平均比顺序计划缩短了 22%。这项技术将有助于使用常规圆形圆锥的 CyberKnife 以缩短的治疗时间实现出色的剂量分布。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a2/7948854/423da93c9b99/rraa136f1.jpg

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