Department of Anesthesiology, Division of Regional Anesthesia and Acute Pain Medicine, University of California, 9400 Campus Point Dr, MC 7770, La Jolla, San Diego, CA, 92037, USA.
Department of Surgery, Division of Minimally Invasive Surgery, University of California, La Jolla, San Diego, CA, USA.
World J Surg. 2021 Apr;45(4):1102-1108. doi: 10.1007/s00268-020-05915-2. Epub 2021 Jan 16.
In this retrospective cohort single-institutional study, we report the outcomes of implementing a standardized protocol of multimodal pain management with thoracic epidural analgesia via the acute pain service (APS) for patients undergoing ventral hernia repair with mesh placement and abdominal wall reconstruction.
The primary outcome evaluated was postoperative 72-h opioid consumption, measured in intravenous morphine equivalents (MEQ). Secondary outcomes included hospital length of stay (LOS) among other outcomes. The two cohorts were the APS versus non-APS group, in which the former cohort had an APS providing epidural and multimodal analgesia and the latter utilized pain management per surgical team, which mostly consisted of opioid therapy. Using1:1 propensity-score-matched cohorts, Wilcoxon signed-rank test was used to calculate the differences in outcomes. A p < 0.05 was considered statistically significant.
There were 83 patients, wherein 51 (61.4%) were in the APS group. Between matched cohorts, the non-APS cohort's median [quartiles] total opioid consumption during the first three days was 85.6 mg MEQs [58.9, 112.8 mg MEQs]. The APS cohort was 31.7 mg MEQs [16.0, 55.3 mg MEQs] (p < 0.0001). The non-APS hospital LOS median [quartiles] was 5 days [4, 7 days] versus 4 days [4, 5 days] in the APS group (p = 0.01).
A dedicated APS was associated with decreased opioid consumption by 75%, as well as a decreased hospital LOS. We report no differences in ICU length of stay, time to oral intake, time to ambulation or time to urinary catheter removal.
在这项回顾性队列单机构研究中,我们报告了通过急性疼痛服务(APS)实施多模式疼痛管理标准化方案(包括胸段硬膜外镇痛)治疗接受网片置入和腹壁重建的腹侧疝修补术患者的结果。
主要观察指标是术后 72 小时内的阿片类药物消耗量,以静脉注射吗啡等效物(MEQ)测量。次要观察指标包括住院时间(LOS)等其他结果。两个队列分别为 APS 组和非 APS 组,前者由 APS 提供硬膜外和多模式镇痛,后者则由手术团队提供疼痛管理,主要包括阿片类药物治疗。使用 1:1 倾向评分匹配队列,采用 Wilcoxon 符号秩检验计算结果差异。p 值<0.05 被认为具有统计学意义。
共有 83 例患者,其中 51 例(61.4%)在 APS 组。在匹配队列中,非 APS 组前三天的总阿片类药物消耗量中位数[四分位数间距]为 85.6 mg MEQs[58.9,112.8 mg MEQs]。APS 组为 31.7 mg MEQs[16.0,55.3 mg MEQs](p<0.0001)。非 APS 组的中位住院时间[四分位数间距]为 5 天[4,7 天],APS 组为 4 天[4,5 天](p=0.01)。
专门的 APS 可使阿片类药物消耗量减少 75%,并降低住院时间。我们报告 ICU 住院时间、开始口服摄入时间、开始活动时间和拔除导尿管时间无差异。