Rettenmaier M A, Moran M F, Ramsinghani N F, Colman M, Syed N A, Puthawala A, Jansen F W, DiSaia P J
Department of Obstetrics and Gynecology, University of California Irvine Medical Center, Orange 92668.
Cancer. 1988 Apr 1;61(7):1301-3. doi: 10.1002/1097-0142(19880401)61:7<1301::aid-cncr2820610704>3.0.co;2-u.
Twelve patients with primary or locally recurrent squamous carcinoma of the cervix were treated with constant internal iliac artery infusion of cisplatin (CDDP) via a totally implantable chemotherapy pump. Seven previously untreated patients received standard external and interstitial radiotherapy (RT) in conjunction with CDDP infusion. Five patients with isolated pelvic recurrences received CDDP therapy only. The chemotherapy pump was refilled weekly on an outpatient basis. All nine evaluable patients developed unilateral or bilateral lower extremity pain which responded to dosage reduction. No renal or marrow toxicity was seen. Both of the evaluable patients treated for recurrent tumor died 32 and 60 weeks after initiation of treatment. The seven patients treated primarily with RT + CDDP infusion include one who expired with persistent tumor and one with no evidence of disease (NED) after exenteration for a pelvic recurrence at 48 and 85 weeks respectively. The five remaining patients are NED at 12 to 60 weeks. Constant internal iliac artery infusion of CDDP via an implantable chemotherapy pump can be performed with acceptable toxicity. The preliminary results suggest that further study in previously untreated undergoing concurrent radiotherapy is warranted.
12例原发性或局部复发性子宫颈鳞状癌患者通过完全植入式化疗泵持续进行髂内动脉顺铂（CDDP）灌注治疗。7例既往未接受过治疗的患者接受了标准的体外和组织间放疗（RT）并联合CDDP灌注。5例孤立性盆腔复发患者仅接受CDDP治疗。化疗泵每周在门诊进行重新灌注。所有9例可评估患者均出现单侧或双侧下肢疼痛，减少剂量后疼痛缓解。未观察到肾脏或骨髓毒性。2例接受复发性肿瘤治疗的可评估患者在开始治疗后32周和60周死亡。7例主要接受RT+CDDP灌注治疗的患者中，1例分别在48周和85周因持续性肿瘤死亡，1例在盆腔复发行盆腔脏器清除术后无疾病证据（NED）。其余5例患者在12至60周时处于NED状态。通过植入式化疗泵持续进行髂内动脉CDDP灌注治疗的毒性可接受。初步结果表明，对既往未接受过治疗且正在接受同步放疗的患者进行进一步研究是有必要的。
