Feron V J, Bruyntjes J P, Woutersen R A, Immel H R, Appelman L M
TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands.
Cancer Lett. 1988 Feb;39(1):101-11. doi: 10.1016/0304-3835(88)90045-6.
Male Wistar rats were exposed to 0, 10 or 20 ppm formaldehyde vapour for 4, 8 or 13 weeks (6 h/day; 5 days/week), and were then observed for periods up to 126 weeks. Transient growth retardation occurred in both test groups. Death rate was not noticeably affected by formaldehyde. Despite recovery periods of at most 126 weeks, the nasal respiratory and olfactory epithelium of many rats of the 20 ppm group exhibited non-neoplastic histopathological changes. Similar but much less severe changes of the respiratory epithelium were seen in a small number of rats of the 10 ppm group; the olfactory epithelium was not visibly affected in rats of this group. Nasal tumours considered to be induced by formaldehyde were seen only in the 20 ppm group and mainly in rats that had been exposed for 13 weeks, the incidence being 4.5% (6/132). These tumours comprised 3 squamous cell carcinomas, 1 carcinoma in situ and 2 polypoid adenomas, all originating from respiratory epithelium. It was concluded that rat nasal respiratory epithelium severely damaged by formaldehyde vapour often does not regenerate and in some cases develops tumours.
将雄性Wistar大鼠暴露于浓度为0、10或20 ppm的甲醛蒸气中4、8或13周（每天6小时；每周5天），然后观察长达126周的时间。两个试验组均出现短暂的生长迟缓。甲醛对死亡率没有明显影响。尽管恢复期最长为126周，但20 ppm组的许多大鼠的鼻呼吸上皮和嗅上皮出现了非肿瘤性组织病理学变化。10 ppm组的少数大鼠的呼吸上皮也出现了类似但程度较轻的变化；该组大鼠的嗅上皮未受明显影响。仅在20 ppm组中发现了被认为是由甲醛诱导的鼻肿瘤，且主要出现在暴露13周的大鼠中，发病率为4.5%（6/132）。这些肿瘤包括3例鳞状细胞癌、1例原位癌和2例息肉状腺瘤，均起源于呼吸上皮。得出的结论是，被甲醛蒸气严重损伤的大鼠鼻呼吸上皮通常无法再生，在某些情况下会发展为肿瘤。
