School of Pharmacy, Nantong University, Nantong, China.
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Jul;12(4):e1614. doi: 10.1002/wnan.1614. Epub 2020 Feb 3.
Chemodynamic therapy (CDT) takes the advantages of Fenton-type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable reactive oxygen species generation exhibits preferable therapeutic performance and satisfying biosafety. In this review article, we summarized the recent advances of stimuli-activatable nanomedicines for CDT. We also overviewed the strategies for augmenting CDT performance, including increasing the catalytic efficacy through rational design of the nanomaterials, modulating the reaction condition, inputting external energy field, and regulating the tumor microenvironment. Furthermore, we discussed the potential and challenges of stimuli-activatable nanomedicine for clinical translation and future development of CDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.
化学动力学治疗（CDT）利用内源性化学能量触发的芬顿型反应来产生高细胞毒性的羟自由基。作为一种新型的癌症治疗模式，CDT 通过响应肿瘤的酸性和高浓度过氧化氢微环境，表现出最小的侵入性和高肿瘤特异性。用于时空可控活性氧生成的 CDT 方法表现出更好的治疗性能和令人满意的生物安全性。在这篇综述文章中，我们总结了用于 CDT 的刺激激活纳米药物的最新进展。我们还概述了增强 CDT 性能的策略，包括通过合理设计纳米材料来提高催化效率、调节反应条件、输入外部能量场以及调节肿瘤微环境。此外，我们讨论了刺激激活纳米药物用于临床转化和 CDT 未来发展的潜力和挑战。本文属于以下类别：治疗方法和药物发现 > 肿瘤纳米医学 纳米生物技术在生物学中的应用 > 生物学中的纳米系统 诊断工具 > 体内纳米诊断和成像。
