Shalini Sorout, Frank Derek S, Aldoukhi Ali H, Majdalany Sami E, Roberts William W, Ghani Khurshid R, Matzger Adam J
Department of Chemistry and the Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, Michigan 48109, United States.
Division of Endourology, Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, United States.
ACS Biomater Sci Eng. 2020 Sep 14;6(9):5274-5280. doi: 10.1021/acsbiomaterials.0c00790. Epub 2020 Jul 31.
Understanding the chemical characteristics of kidney stones and how the stone composition affects their fragmentation is key to improving clinical laser lithotripsy. During laser lithotripsy, two mechanisms may be responsible for stone fragmentation: a photothermal mechanism and/or microexplosion mechanism. Herein, we carry out an isotopic substitution of crystal HO with DO in calcium oxalate monohydrate and struvite stones to alter their optical properties to study the relationship between the absorption of the stones, at the wavelength of the Ho:YAG (2.12 μm) laser, and the fragmentation behavior. Changing the absorption of the stones at 2.12 μm changes the extent of fragmentation, whereas changing the absorption of the bulk medium has a negligible effect on fragmentation, leading to the conclusion that kidney stone ablation is dominated by a photothermal mechanism.
了解肾结石的化学特性以及结石成分如何影响其破碎，是改善临床激光碎石术的关键。在激光碎石过程中，结石破碎可能由两种机制引起：光热机制和/或微爆炸机制。在此，我们对一水合草酸钙结石和鸟粪石结石中的晶体HO进行DO同位素取代，以改变其光学性质，从而研究结石在钬:钇铝石榴石（Ho:YAG，波长2.12μm）激光波长下的吸收与破碎行为之间的关系。改变结石在2.12μm处的吸收会改变破碎程度，而改变主体介质的吸收对破碎的影响可忽略不计，由此得出肾结石消融主要由光热机制主导的结论。
