Wave Propagation and Energy Dissipation in Collagen Molecules.

Collagen is the key protein of connective tissue (i.e., skin, tendons and ligaments, and cartilage, among others), accounting for 25-35% of the whole-body protein content and conferring mechanical stability. This protein is also a fundamental building block of bone because of its excellent mechanical properties together with carbonated hydroxyapatite minerals. Although the mechanical resilience and viscoelasticity have been studied both in vitro and in vivo from the molecular to tissue level, wave propagation properties and energy dissipation have not yet been deeply explored, in spite of being crucial to understanding the vibration dynamics of collagenous structures (e.g., eardrum, cochlear membranes) upon impulsive loads. By using a bottom-up atomistic modeling approach, here we study a collagen peptide under two distinct impulsive displacement loads, including longitudinal and transversal inputs. Using a one-dimensional string model as a model system, we investigate the roles of hydration and load direction on wave propagation along the collagen peptide and the related energy dissipation. We find that wave transmission and energy-dissipation strongly depend on the loading direction. Also, the hydrated collagen peptide can dissipate five times more energy than dehydrated one. Our work suggests a distinct role of collagen in term of wave transmission of different tissues such as tendon and eardrum. This study can step toward understanding the mechanical behavior of collagen upon transient loads, impact loading and fatigue, and designing biomimetic and bioinspired materials to replace specific native tissues such as the tympanic membrane.