Ezequiel Dias Foundation, Health Public Laboratory of Minas Gerais State , Belo Horizonte, Brazil.
Department of Food Science (ALM), Faculty of Pharmacy (FAFAR), Federal University of Minas Gerais (UFMG) , Belo Horizonte, Brazil.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021 Feb;38(2):315-325. doi: 10.1080/19440049.2020.1852321. Epub 2021 Jan 16.
A risk assessment was performed to estimate the lead (Pb) dietary intake in the Brazilian population. Data on Pb concentration in food were obtained through a systematic review with meta-analyses and from the GEMS/Food database, both involving data through 2018. Food consumption data were obtained from a Brazilian official dietary survey. Pb dietary intakes were estimated by a deterministic approach. Risk characterisation was conducted using the margin of exposure approach (MOE). The total Pb intake in the Brazilian population ranged from 1.53 to 2.01 μg/kg bw/day. Major contributors to Pb dietary exposure were the vegetable and vegetable products and beverage categories. From the results obtained, a risk of increased systolic pressure, nephrotoxicity and decrease of 0.5 point intelligence quotient can be expected, MOE<1, with greater magnitudes of risk observed for men in rural areas and in the Midwest, Southeast and South Brazilian regions. The dietary risk assessment indicates a health concern for the Brazilian population associated with Pb dietary intake.
进行了风险评估，以估计巴西人口的铅 (Pb) 饮食摄入量。通过系统评价和 GEMS/Food 数据库（均涉及 2018 年的数据）获取食物中 Pb 浓度的数据。食物消费数据来自巴西一项官方饮食调查。通过确定性方法估计 Pb 饮食摄入量。采用暴露量与安全限量比值法（MOE）进行风险特征描述。巴西人口的总 Pb 摄入量范围为 1.53 至 2.01μg/kg bw/day。Pb 饮食暴露的主要来源是蔬菜和蔬菜制品以及饮料类别。根据所获得的结果，预计会出现收缩压升高、肾毒性和智商下降 0.5 点的风险，MOE<1，在农村地区以及中西部、东南部和南部巴西地区，男性的风险程度更大。饮食风险评估表明，巴西人口的 Pb 饮食摄入与健康有关。
