Social Determinants of Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Medical Entomology Department, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran.
Syst Rev. 2021 Jan 18;10(1):30. doi: 10.1186/s13643-021-01578-9.
Malaria is the most common vector-borne disease transmitted to humans by Anopheles mosquitoes. Endectocides and especially ivermectin will be available as a vector control tool soon. The current review could be valuable for trial design and clinical studies to control malaria transmission.
PubMed/MEDLINE, Scopus, Web of Science, and Science Direct were searched for original English published papers on ("Malaria chemical control" OR "Malaria elimination" OR "Anopheles vector control" OR "Malaria zooprophylaxis") AND ("Systemic insecticides" OR "Endectocides" OR "Ivermectin"). The last search was from 19 June 2019 to 31 December 2019. It was updated on 17 November 2020. Two reviewers (SG and FGK) independently reviewed abstracts and full-text articles. Data were extracted by one person and checked by another. As meta-analyses were not possible, a qualitative summary of results was performed.
Thirty-six published papers have used systemic insecticides/endectocides for mosquito control. Most of the studies (56.75%) were done on Anopheles gambiae complex species on doses from 150 μg/kg to 400 μg/kg in several studies. Target hosts for employing systemic insecticides/drugs were animals (44.2%, including rabbit, cattle, pig, and livestock) and humans (32.35%).
Laboratory and field studies have highlighted the potential of endectocides in malaria control. Ivermectin and other endectocides could soon serve as novel malaria transmission control tools by reducing the longevity of Anopheles mosquitoes that feed on treated hosts, potentially decreasing Plasmodium parasite transmission when used as mass drug administration (MDA).
疟疾是由疟蚊传播给人类的最常见的虫媒病。伊维菌素等内吸性杀虫剂很快将作为一种病媒控制工具问世。本综述对于控制疟疾传播的临床试验设计和临床研究可能具有重要价值。
检索了 PubMed/MEDLINE、Scopus、Web of Science 和 Science Direct 上发表的关于“疟疾化学控制”或“疟疾消除”或“按蚊病媒控制”或“疟疾动物防治”和“全身杀虫剂”或“内吸性杀虫剂”或“伊维菌素”的原始英文文献。最后一次搜索是在 2019 年 6 月 19 日至 2019 年 12 月 31 日。2020 年 11 月 17 日进行了更新。两名评审员（SG 和 FGK）独立审查了摘要和全文文章。由一个人提取数据，由另一个人核对。由于无法进行荟萃分析，因此对结果进行了定性总结。
已有 36 篇已发表的论文使用了全身杀虫剂/内吸性杀虫剂来控制蚊子。大多数研究（56.75%）是在几种剂量为 150μg/kg 至 400μg/kg 的冈比亚按蚊复合体物种上进行的。使用全身杀虫剂/药物的目标宿主是动物（44.2%，包括兔子、牛、猪和牲畜）和人类（32.35%）。
实验室和现场研究强调了内吸性杀虫剂在疟疾控制中的潜力。伊维菌素和其他内吸性杀虫剂很快将作为一种新的疟疾传播控制工具，通过减少吸食受处理宿主的按蚊寿命，在用作大规模药物治疗（MDA）时，可能会降低疟原虫寄生虫的传播。
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