1Division of Clinical Immunology, Allergology and Rheumatology, Department of Internal Medicine, Dubrava University Hospital, Zagreb, Croatia; 2Division of Hematology, Department of Internal Medicine, School of Medicine, University of Zagreb, Dubrava University Hospital, Zagreb, Croatia; 3Division of Clinical Immunology, Pulmonology and Rheumatology, Department of Internal Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.
Acta Clin Croat. 2020 Jun;59(2):312-317. doi: 10.20471/acc.2020.59.02.15.
The aim of this study was to investigate the association of smoking with disease activity, seropositivity, age and gender in patients with rheumatoid arthritis. We included 89 rheumatoid arthritis patients. All patients fulfilled the 2010 American College of Rheumatology/European League Against Rheumatism rheumatoid arthritis classification criteria. Activity of the disease was measured by Disease Activity Score 28-joint count C-reactive protein (DAS28CRP). The subjects were stratified into smoking and non-smoking groups and cross-sectionally analyzed. There were 24 (27%) smokers and 65 (73%) nonsmokers. The mean age of patients was 57.1±8.8 years. The mean DAS28CRP was 5.81 in the smoking group and 5.57 in the non-smoking group, without statistically significant difference between the two groups (p=0.148). Similarly, smokers did not differ significantly from non-smokers according to age (p=0.443), gender (p=0.274), rheumatoid factor positivity (p=0.231), anti-citrullinated protein antibody positivity (p=0.754) or seropositivity (p=0.163). In this study, we found no association between smoking status and disease activity, seropositivity, age or gender in rheumatoid arthritis patients. Furthermore, disease activity was not related to age, gender or seropositivity. Additional studies on the effects of smoking on rheumatoid arthritis activity are needed.
本研究旨在探讨吸烟与类风湿关节炎患者的疾病活动度、血清阳性、年龄和性别之间的关系。我们纳入了 89 例类风湿关节炎患者。所有患者均符合 2010 年美国风湿病学会/欧洲抗风湿病联盟类风湿关节炎分类标准。疾病活动度通过 28 个关节的疾病活动评分（DAS28）和 C 反应蛋白（DAS28CRP）来衡量。将患者分为吸烟和非吸烟组，并进行横断面分析。其中吸烟者 24 例（27%），非吸烟者 65 例（73%）。患者平均年龄为 57.1±8.8 岁。吸烟组的平均 DAS28CRP 为 5.81，非吸烟组为 5.57，两组间无统计学差异（p=0.148）。同样，吸烟者在年龄（p=0.443）、性别（p=0.274）、类风湿因子阳性（p=0.231）、抗瓜氨酸化蛋白抗体阳性（p=0.754）或血清阳性（p=0.163）方面与非吸烟者也无显著差异。在本研究中，我们未发现吸烟状况与类风湿关节炎患者的疾病活动度、血清阳性、年龄或性别之间存在关联。此外，疾病活动度与年龄、性别或血清阳性无关。需要进一步研究吸烟对类风湿关节炎活动度的影响。
