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万古霉素诱导的线状IgA大疱性皮肤病。

Vancomycin-induced linear IgA bullous dermatosis.

作者信息

Wiggins Claire J, Chon Susan Y

机构信息

Department of Dermatology, MD Anderson Cancer Center, Houston, Texas.

出版信息

Proc (Bayl Univ Med Cent). 2020 Aug 26;34(1):83-84. doi: 10.1080/08998280.2020.1809759.

DOI:10.1080/08998280.2020.1809759
PMID:33456152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7785186/
Abstract

Adverse medication side effects are not uncommon in the inpatient setting, where polypharmacy is the norm. Linear IgA bullous dermatosis (LABD) can be a cutaneous side effect of commonly used inpatient medications, such as vancomycin. Symptoms of LABD can be severe, and proper recognition of this drug-induced disease is important to ensuring proper treatment, including the removal of the inciting agent. This report describes a case of vancomycin-associated LABD in a 66-year-old man and the proper management of drug-induced LABD.

摘要

药物不良反应在住院患者中并不罕见,在这种情况下,联合用药是常态。线状IgA大疱性皮肤病(LABD)可能是常用住院药物(如万古霉素)的皮肤不良反应。LABD的症状可能很严重,正确识别这种药物引起的疾病对于确保正确治疗(包括停用诱发药物)很重要。本报告描述了一名66岁男性万古霉素相关LABD病例以及药物性LABD的正确管理。

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本文引用的文献

1
Drug-induced Linear IgA Bullous Dermatosis: A Case Report and Review of the Literature.药物诱导的线性 IgA 大疱性皮病:病例报告及文献复习。
Acta Derm Venereol. 2019 May 1;99(6):508-515. doi: 10.2340/00015555-3154.
2
Idiopathic linear IgA bullous dermatosis: prognostic factors based on a case series of 72 adults.特发性线状 IgA 大疱性皮病:基于 72 例成人病例系列的预后因素。
Br J Dermatol. 2017 Jul;177(1):212-222. doi: 10.1111/bjd.15244. Epub 2017 May 15.
3
Linear IgA bullous disease presenting as toxic epidermal necrolysis: a case report and review of the literature.表现为中毒性表皮坏死松解症的线状IgA大疱性疾病:一例病例报告及文献复习
Dermatology. 2013;227(3):209-13. doi: 10.1159/000353584. Epub 2013 Oct 11.
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Vasculopathy, inflammation, and blood flow in leg ulcers of patients with sickle cell anemia.镰状细胞贫血患者腿部溃疡中的血管病变、炎症和血流。
Am J Hematol. 2014 Jan;89(1):1-6. doi: 10.1002/ajh.23571. Epub 2013 Sep 19.
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Linear IgA bullous dermatosis: comparison between the drug-induced and spontaneous forms.线性 IgA 大疱性皮病:药物诱导型与自发性的比较。
Br J Dermatol. 2013 Nov;169(5):1041-8. doi: 10.1111/bjd.12488.
6
Vancomycin-induced linear IgA bullous disease presenting as toxic epidermal necrolysis.表现为中毒性表皮坏死松解症的万古霉素诱导的线状IgA大疱性疾病。
Clin Exp Dermatol. 2004 Nov;29(6):633-6. doi: 10.1111/j.1365-2230.2004.01649.x.
7
Vancomycin-induced linear IgA disease manifesting as bullous erythema multiforme.万古霉素诱导的线状IgA疾病,表现为大疱性多形红斑。
J Cutan Pathol. 2004 May;31(5):393-7. doi: 10.1111/j.0303-6987.2004.00190.x.
8
Use of 1M NaCl split skin in the indirect immunofluorescence of the linear IgA bullous dermatoses.
J Cutan Pathol. 1990 Jun;17(3):144-8. doi: 10.1111/j.1600-0560.1990.tb00073.x.