O'Connell Cailin, Dacy Nicole N, Brown Shannon C, Lopez Lisa
Engineering Medicine, Texas A&M School of Medicine, Houston, USA.
Department of Dermatology, Baylor Scott & White Health, Temple, USA.
Cureus. 2023 May 5;15(5):e38592. doi: 10.7759/cureus.38592. eCollection 2023 May.
We present a rare case of linear IgA bullous dermatosis (LABD) in a 72-year-old male associated with the use of azithromycin. LABD presents as subepidermal blisters due to IgA antibodies targeting BPAG2, a component of hemidesmosomes. LABD is a rare diagnosis and may be idiopathic, associated with illness, or medication-induced. The patient experienced a rash five days after completing a course of azithromycin for pneumonia. The diagnosis of LABD was confirmed with a biopsy and direct immunofluorescence. Lesions resolved over two weeks with an oral prednisone taper and topical clobetasol. This case represents just one of two previously reported cases in the literature of azithromycin-associated LABD. While LABD is well known to be induced by certain medications, this is only the second report of it being associated with the use of a macrolide. We propose that macrolides be included as a potential cause of medication-induced LABD.
我们报告了一例72岁男性使用阿奇霉素后发生的罕见线性IgA大疱性皮肤病（LABD）病例。LABD表现为由于IgA抗体靶向半桥粒的一种成分BPAG2而导致的表皮下水疱。LABD是一种罕见的诊断，可能是特发性的，与疾病相关，或由药物引起。该患者在完成一个疗程的阿奇霉素治疗肺炎五天后出现皮疹。通过活检和直接免疫荧光确诊为LABD。皮损在口服泼尼松逐渐减量和外用氯倍他索的情况下在两周内消退。该病例是文献中先前报道的两例阿奇霉素相关LABD病例之一。虽然众所周知LABD可由某些药物诱发，但这是其与大环内酯类药物使用相关的第二例报道。我们建议将大环内酯类药物列为药物诱发LABD的潜在原因之一。
