Konstantinidou Sofia K, Kostaras Penelope, Anagnostopoulos Georgios-Eleftherios, Markantonis Sophia-Liberty, Karalis Vangelis, Konstantinidis Konstantinos
Clinical Pharmacy Department, Athens Medical Center, 15125 Athens, Greece.
Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Exp Ther Med. 2021 Feb;21(2):174. doi: 10.3892/etm.2020.9605. Epub 2020 Dec 27.
Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder requiring lifestyle adaptations and administration of medications. Another approach is the surgical treatment of GERD through laparoscopic or robotic operations. The aim of the present study was to investigate the improvement of symptoms and quality of life of patients with GERD, before and after robotic surgical restoration using the Nissen robotic fundoplication technique. The potential effects of body weight, age and sex, as well as the response to medications and progress over time, were also assessed. A retrospective study was conducted in a tertiary hospital between October 2019 and March 2020. Data were collected and recorded from 144 patients who underwent robotic surgery, using the Nissen fundoplication technique, during the period 2009-2019. All patients involved in this analysis pre-operatively exhibited severe symptoms of heartburn and reflux, as well as poor quality of life. All of these symptoms were re-examined after surgery, and a marked decrease was observed with respect to their frequency and intensity. Improvement was not affected by body mass index, whereas older patients exhibited greater improvement. Women initially experienced more severe symptoms before the surgery, but they appeared to respond as well as the male patients. The long-term beneficial effects of surgery for up to the 10-year period studied were validated. After the robotic surgical rehabilitation, the vast majority of patients overcame the unpleasant symptoms of GERD and stayed off their medications. More than 4/5 of the patients were satisfied after surgery. In conclusion, restoration of GERD, using Nissen robotic fundoplication, led to the minimization of symptoms and to a marked improvement in the quality of life of patients.
胃食管反流病（GERD）是一种常见的胃肠道疾病，需要调整生活方式并服用药物。另一种治疗方法是通过腹腔镜或机器人手术对GERD进行外科治疗。本研究的目的是调查使用nissen机器人胃底折叠术进行机器人手术修复前后GERD患者症状和生活质量的改善情况。还评估了体重、年龄和性别等潜在影响因素，以及对药物的反应和随时间的进展情况。2019年10月至2020年3月期间在一家三级医院进行了一项回顾性研究。收集并记录了2009年至2019年期间144例行nissen胃底折叠术机器人手术患者的数据。所有参与本分析的患者术前均表现出严重的烧心和反流症状，以及生活质量较差。术后对所有这些症状进行了复查，发现其频率和强度均显著降低。改善情况不受体重指数的影响，而老年患者改善更为明显。女性患者术前最初症状更严重，但术后反应与男性患者相当。手术在长达10年的研究期内的长期有益效果得到了验证。机器人手术康复后，绝大多数患者克服了GERD的不适症状，不再服药。超过4/5的患者术后感到满意。总之，使用nissen机器人胃底折叠术修复GERD可使症状最小化，并显著改善患者的生活质量。
