尼日利亚东北部包奇州阿卜杜勒·塔法瓦·巴莱瓦教学医院隔离中心收治的成年 COVID-19 患者的临床和实验室特征。

Clinical and laboratory characteristics of COVID-19 among adult patients admitted to the isolation centre at Abubakar Tafawa Balewa Teaching Hospital Bauchi, Northeast Nigeria.

机构信息

Department of Internal Medicine, Aabubakar Tafawa Balewa University Teaching Hospital, Bauchi, Nigeria.

Department of Medical Microbiology, Federal Medical Centre, Makurdi, Nigeria.

出版信息

Pan Afr Med J. 2020 Oct 22;37(Suppl 1):27. doi: 10.11604/pamj.supp.2020.37.27.26162. eCollection 2020.

DOI:10.11604/pamj.supp.2020.37.27.26162

PMID:33456651

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7796845/

Abstract

INTRODUCTION

as the epidemiological trend of COVID-19 infection continue to evolve with increasing prevalence and incidence globally, management of cases in low-resource health care settings require basic detailed clinical and laboratory characteristics. This study retrospectively described the clinical and laboratory characteristics of confirmed COVID-19 cases admitted into the isolation centre of ATBUTH, Bauchi.

METHODS

clinical and laboratory data of 84 confirmed COVID-19 cases admitted into the isolation centre of ATBUTH, Bauchi according to NCDC guidelines were used. Diagnosis was based on nasal and nasopharyngeal swab positive result of reverse transcriptase-polymerase chain reaction (RT-PCR) result. Data extracted includes demographic, clinical presentations and laboratory characteristics.

RESULTS

the 84 COVID-19 patients comprised of 72% (59) males and 28% (25) females with mean age of 41.0±10.5 years, majority of the patients were within age-group 21-40 years. Forty-one percent presented with mild to moderate symptoms, 3.6% (3) presented with severe symptoms while 58.3% (49) were asymptomatic with mean body temperature of 36.60C ± Sá. The common clinical manifestations were fever 23.4% (19) and cough 20.7% (17). About 29.3% of the patients had comorbidities, 17.1% (14) were hypertensive while 12.2% of the diabetic. Thirty percent (10) of the patients with DM required intensive care unit (ICU) admission with 10% mortality. Biochemical parameters were within normal range for all the patients. However, haematological parameters showed increased neutrophil (10, 43.5%) and lymphocyte count (19 (59.4%).

CONCLUSION

the study findings revealed high number of asymptomatic cases, similarity in clinical manifestation and relatively normal laboratory characteristics. More experience with increase in number of patients may provide additional information. Interrupting community transmission will require early detection and contact trace of asymptomatic cases.

摘要

引言

随着全球 COVID-19 感染的流行病学趋势不断演变，发病率和患病率不断上升，在资源匮乏的医疗环境中管理病例需要基本的详细临床和实验室特征。本研究回顾性描述了在包奇州立教学医院隔离中心收治的确诊 COVID-19 病例的临床和实验室特征。

方法

根据 NCDC 指南，使用了在包奇州立教学医院隔离中心收治的 84 例确诊 COVID-19 病例的临床和实验室数据。诊断基于鼻和鼻咽拭子逆转录-聚合酶链反应（RT-PCR）结果阳性。提取的数据包括人口统计学、临床表现和实验室特征。

结果

84 例 COVID-19 患者中，72%（59 例）为男性，28%（25 例）为女性，平均年龄为 41.0±10.5 岁，大多数患者年龄在 21-40 岁之间。41%的患者表现为轻度至中度症状，3.6%（3 例）表现为严重症状，58.3%（49 例）无症状，平均体温为 36.60C±Sá。常见的临床表现为发热 23.4%（19 例）和咳嗽 20.7%（17 例）。约 29.3%的患者有合并症，17.1%（14 例）为高血压，12.2%的患者为糖尿病。30%（10 例）的糖尿病患者需要入住重症监护病房（ICU），死亡率为 10%。所有患者的生化参数均在正常范围内。然而，血液学参数显示中性粒细胞（10 例，43.5%）和淋巴细胞计数（19 例，59.4%）增加。