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一例慢性髓性白血病原始细胞危象伴严重治疗相关免疫抑制的重症 COVID-19 感染患者:病例报告。

Severe COVID-19 infection in a patient with a blastic transformation of a chronic myeloid leukemia and severe treatment-induced immunosuppression: a case report.

机构信息

Medical Intensive Care Unit, Ibn Rochd University Hospital of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco.

Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.

出版信息

Pan Afr Med J. 2020 Nov 11;37(Suppl 1):34. doi: 10.11604/pamj.supp.2020.37.34.25501. eCollection 2020.

DOI:10.11604/pamj.supp.2020.37.34.25501
PMID:33456658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7796834/
Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread across the globe, leading to the declaration of a pandemic. While most present mild symptoms, it appears as though nearly 20% of confirmed patients develop significant complications. At this time of uncertainty, we are struggling to provide appropriate care to hematological cancer patients. We need to weigh the risks and benefits of giving cancer treatment against the odds of infecting them with COVID-19. As hematological cancer patients are immunocompromised and there are high chances of exposure during hospital visits, they can get infected and outcome can be fatal. So in this case report, we intend to discuss the possible impact of the current COVID-19 pandemic on patients with acute leukaemia in terms of diagnosis, chemotherapy, and prophylactic measures.

摘要

严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)迅速在全球范围内传播,导致宣布大流行。虽然大多数人症状轻微,但似乎近 20%的确诊患者出现严重并发症。在这个不确定的时期,我们正在努力为血液癌症患者提供适当的护理。我们需要权衡给予癌症治疗的风险和益处,以及感染 COVID-19 的几率。由于血液癌症患者免疫功能低下,并且在医院就诊期间有很高的暴露风险,他们可能会感染,而且结果可能是致命的。因此,在本病例报告中,我们打算讨论当前 COVID-19 大流行对急性白血病患者在诊断、化疗和预防措施方面的可能影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36cd/7796834/cc33e6499be9/PAMJ-SUPP-37-1-34-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36cd/7796834/b3b887961ed3/PAMJ-SUPP-37-1-34-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36cd/7796834/cc33e6499be9/PAMJ-SUPP-37-1-34-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36cd/7796834/b3b887961ed3/PAMJ-SUPP-37-1-34-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36cd/7796834/cc33e6499be9/PAMJ-SUPP-37-1-34-g002.jpg

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本文引用的文献

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Special considerations in the management of adult patients with acute leukaemias and myeloid neoplasms in the COVID-19 era: recommendations from a panel of international experts.2019冠状病毒病(COVID-19)时代成人急性白血病和髓系肿瘤患者管理的特殊考量:国际专家小组的建议
Lancet Haematol. 2020 Aug;7(8):e601-e612. doi: 10.1016/S2352-3026(20)30205-2. Epub 2020 Jun 18.
2
COVID-19 in persons with haematological cancers.COVID-19 与血液系统恶性肿瘤。
Leukemia. 2020 Jun;34(6):1637-1645. doi: 10.1038/s41375-020-0836-7. Epub 2020 Apr 24.
3
Acute leukemia in the time of COVID-19.
新冠疫情期间的急性白血病
Leuk Res. 2020 Mar 26;92:106353. doi: 10.1016/j.leukres.2020.106353.